Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

By Tomoyuki U. Tanaka, N. Rachidi, C. Janke, G. Pereira, M. Gálová, E. Schiebel, M. Stark, Kim Nasmyth. Cell, 2002

821 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/85390d2d4274fa4bf5647c5dab0e4d3217072a9b

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In Cell Biology

1. Beth A. Weaver
2. R. Medema
3. S. Lens
4. E. Voest
5. J. Peters
6. D. Cleveland
7. M. Carmena
8. Hugo Ceulemans

In Molecular Biology

1. Beth A. Weaver
2. R. Medema
3. S. Lens
4. E. Voest
5. J. Peters
6. D. Cleveland
7. A. Musacchio
8. A. Brunet

Citations in the corpus

• Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. (2006, neutral): “…of Hec1 is involved in regulating attachment/detachment and plus-end assembly dynamics of kMTs. Ipl1p kinase has been shown to function in destabilizing kMT attachment to prevent errors in chromosome segregation in budding yeast (Tanaka et al., 2002; Cheeseman et al., 2002; Pinsky et al., 2006).”
• The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint (2003, background): “…that the Aurora kinase Ipl1 is required both for proper chromosome segregation by destabilizing incorrect kinetochore–microtubule interactions, and for maintaining the spindle assembly checkpoint in the absence of tension (Biggins et al., 1999; Biggins and Murray, 2001; Tanaka et al., 2002).”
• Functional diversity of protein phosphatase-1, a cellular economizer and reset button. (2004, background): “While Aurora-A is required for centrosome separation in animals (147), the unique yeast Aurora kinase does not appear to subserve this function, as a conditional loss-of-function mutation of this enzyme did not affect spindle pole body separation (356).”
• The cellular geography of Aurora kinases (2003, background): “In yeast, Ipl1 has been proposed to promote amphitelic kinetochore attachment to microtubules by destabilizing syntelic attachments of SISTER CHROMATIDS”
• Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “Aurora kinase B destabilizes incorrectly attached microtubules and thereby has an essential role in chromosome bi-orientatio”
• On the road to cancer: aneuploidy and the mitotic checkpoint (2005, background): “Aurora kinase B activity severs improper microtubule attachments that fail to produce tension between sister centromere”
• The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. (2006, background): “In vivo, Aurora B eliminates incorrect kinetochore-microtubule attachments, allowing the reformation of correct bipolar attachments (Tanaka et al., 2002).”