Translational regulation of GCN4 and the general amino acid control of yeast.

By A. Hinnebusch. Annual Review of Microbiology, 2005

1,322 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ce3ba640f556a6e529a5b65c95a7ac4b02ef2fe5

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Citations in the corpus

With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, positive): “Mechanistically, this is driven by short upstream open reading frames in the 50UTR of this gene (Hinnebusch, 2005; Tzamarias et al., 1989).”
An Overview of the Molecular Mechanism of Autophagy (2009, background): “Central to this response is Gcn4, a master transcriptional activator of gene expression (Hinnebusch 2005).”
The integrated stress response (2016, neutral): “This results in preferential synthesis of Gcn4p, a transcription factor that controls the expression of genes involved in amino acid synthesis and transport [138].”
The eIF2α kinases: their structures and functions (2013, neutral): “cerevisiae homologue of ATF4, GCN4 (reviewed in [81]).”
The scanning mechanism of eukaryotic translation initiation. (2014, background): “Consistently, these yeIF2γ mutations derepress translation of GCN4 mRNA in vivo (23), a (Gcd−) phenotype indicating reduced TC recruitment to 40S subunits engaged in reinitiation after translation of the first uORF, uORF1, in this specialized transcript (Supplemental Figure 1b) (17).”
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control (2011, background): “In contrast to the SPS-sensing pathway that is activated by amino acids, the Gcn4 transcription factor is activated upon amino acid starvation (Hinnebusch 2005).”
Nutrient sensing and TOR signaling in yeast and mammals (2017, neutral): “…of amino acid transporters, enzymes involved in amino acid metabolism (Hinnebusch & Natarajan, 2002; Siu et al , 2002; Averous et al , 2004; Hinnebusch, 2005; Kilberg et al , 2009; Staschke et al , 2010), and factors involved in autophagy (B’chir et al , 2013; Fig 2), thereby allowing…”
Pharmacological brake-release of mRNA translation enhances cognitive memory (2013, background): “…13 of 22 Research article and translational induction of a transcriptional activator, GCN4, mediated by uORFs in the 5′UTR of its mRNA (Hinnebusch, 2005). eIF2B is a conserved protein complex comprised of five different subunits, two of which form the catalytic core, and the…”
Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex (2014, background): “Most substitutions of G1575 and A1576 in yeast 18S rRNA are lethal and, in the presence of wild-type rRNA in the same cells, confer a dominant Gcd phenotype (Hinnebusch, 2005), indicating impaired TC binding to the PIC and also increased ‘‘leaky scanning’’ wherein an upstream AUG codon is skipped in”
Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. (2017, background): “By reducing the rate of TC loading, they allow 40S subunits that translate the first uORF and resume scanning to bypass the subsequent uORFs 2–4 and reinitiate at the GCN4 ORF instead [46].”
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “Phosphorylated eIF2a exhibits enhanced affinity for the GTP-GDP exchange factor (GEF) eIF2B, competitively inhibiting the rate of nucleotide exchange, which in turn results in a reduced rate of TC formation (Dever et al., 1993; Hinnebusch, 2005).”
Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation (2020, background): “The 5′-Untranslated Region (5′-UTR) of the GCN4 gene contains 4 upstream AUG (uAUG) codons (28).”
The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae (2012, background): “For example, the GCN4 mRNA is activated via a mechanism involving short upstream open reading frames (Hinnebusch 2005).”