The scanning mechanism of eukaryotic translation initiation.

By A. Hinnebusch. 2014

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In Molecular Biology

Citations in the corpus

Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation (2020, background): “The 48S complex, formed after mRNA recruitment by the 43S-PIC, dynamically scans the mRNA from the 5′ end for an AUG codon in a favorable context (10, 11).”
Toward a Kinetic Understanding of Eukaryotic Translation. (2018, methodology): “Start codon selection is one of the most well-characterized steps in the eukaryotic translation pathway (Lorsch and Dever 2010; Hinnebusch 2014, 2017).”
The Functions of MicroRNAs: mRNA Decay and Translational Repression. (2015, background): “The initiation step of translation is composed of serial reactions that place the P (peptidyl) site of the ribosome on the AUG start codon of an mRNA [144,145].”
Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation (2020, background): “Following mRNA recruitment and directional scanning of the 5′ untranslated region (UTR) to a start codon, a series of compositional and conformational changes occur (25, 26).”
Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. (2017, background): “A Model for the Scanning Mechanism Biochemical, genetic, and structural analyses have led to the following model for the mechanism of scanning (Figure 3; for reviews, see [3,4]).”
Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex (2014, background): “Eukaryotic translation initiation involves at least 12 initiation factors (eIFs) (Hinnebusch, 2014).”