Turning a hobby into a job: How duplicated genes find new functions

By Gavin C. Conant, Kenneth H. Wolfe. Nature reviews genetics, 2008

1,210 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4915d4dae9c2d1c1b49faec26bdfe060f99526a5

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Citations in the corpus

The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs (2010, unknown): “…in an evolutionary mouse lineage may have, for example, enabled sensation of additional species emitting Mups of more divergent sequence (Conant and Wolfe, 2008; McLennan, 2008), initiating an interspecies defense system that increased fitness and futher stabilized Mup detection (Figure…”
Evolution of Gene Duplication in Plants1[OPEN] (2016, background): “…of plant genome sequences and functional genomic data sets, we now have an unprecedented understanding of how genes are duplicated, how duplicated genes evolve new functions, and the impact of gene duplication on genome evolution (Conant and Wolfe, 2008; Freeling et al., 2015; Soltis et al., 2015).”
Whole-genome duplication in teleost fishes and its evolutionary consequences (2014, background): “It is also referred to as “mutation during non-functionality” (MDN) model (Hughes 1994; Conant and Wolfe 2008).”
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, background): “Changes in promoter structure have thus allowed constitutively low levels of expression of GAL3 for better galactose sensing and a tight coordination between GAL1 expression and the galactose concentration to prevent metabolic toxicity (Conant & Wolfe, 2008).”
Teleost fish with specific genome duplication as unique models of vertebrate evolution (2010, background): “…issues in evolutionary biology is duplicate gene evolution, because almost all genes in extant genomes and the proteins that they encode, which have various functions and structures, are thought to have been generated primarily by gene duplication (Ohno 1970; Zhang 2003; Conant and Wolfe 2008).”
The evolution of gene duplications: classifying and distinguishing between models (2010, background): “and have taken place since before the last universal common ancesto”
Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010, unknown): “By virtue of two genes carrying the same level of function, duplication offers a margin that allows a larger variety of potentially beneficial mutations to accumulate provided that, contrary to Ohno’s model, the two genes remain under selection (117, 128, 171).”
Divergence of duplicate genes in exon–intron structure (2012, background): “Second, alternative splicing does not necessarily need the mutation or modification of the genomic sequences, whereas exonization/pseudoexonization requires the creation and/or fixation of a novel start/stop codon (of a gene) or donor/acceptor site (of an intron) (13, 22, 23).”
Panoramic view of a superfamily of phosphatases through substrate profiling (2015, background): “During evolution, if there is a variation in the substrate pool, it is more facile for mutations to change the substrate specificity spectrum of broad, overlapping enzymes— that is, divergence before gene duplication (40, 41).”
Probing the Mutational Interplay between Primary and Promiscuous Protein Functions: A Computational-Experimental Approach (2012, background): “Furthermore, as briefly elaborated below, promiscuity likely plays an essential role in the development of new functions through divergent evolution [3,5,8,16–20].”