Hematopoiesis is severely altered in mice with an induced osteoblast deficiency.

By D. Visnjic, Z. Kalajzic, D. Rowe, V. Katavić, J. Lorenzo, H. Aguila. Blood, 2004

822 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Orthopedics and Sports Medicine

View Paper: https://www.semanticscholar.org/paper/cc1d205c444cd45dcd72c305fcddd5e48e504320

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. A. Trumpp
2. Anne Wilson
3. T. Xie
4. Linheng Li
5. A. Wagers

In Molecular Biology

1. Linheng Li
2. W. Neaves
3. A. Trumpp
4. Anne Wilson
5. M. Zaidi
6. T. Xie
7. Soo Young Lee
8. D. L. Jones

In Orthopedics and Sports Medicine

1. M. Zaidi

Citations in the corpus

• c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “BM stem cell niches are thought to be located in the endosteal lining of trabecular BM cavities, with ostoblastic cells being a crucial component of the stem cell-maintaining niche (Nilsson et al. 2001; Calvi et al. 2003; Visnjic et al. 2004).”
• Bone-marrow haematopoietic-stem-cell niches (2006, methodology): “This concept is supported by experiments in which osteoblasts were conditionally ablated by targeting the expression of thymidine kinase (which induces cell death in response to ganciclovir (Cytovene, Roche), to the osteoblast lineag”
• No place like home: anatomy and function of the stem cell niche (2008, background): “Finally, increasing evidence implicates deregulation of the stem cell niche as a proximal cause of many pathologies associated with tissue degeneratio”
• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “Changes in osteoblast numbers have been demonstrated to alter the number of HSC niches (7, 15).”
• Normal stem cells and cancer stem cells: the niche matters. (2006, background): “Increasing the niche size in mice leads to an increased number of hematopoietic stem cells (21), and in contrast, depleting the osteoblastic lining cells leads to depletion of hematopoietic tissue (55).”
• Stem cell niche: structure and function. (2005, background): “In vitro coculture of HSCs with osteoblasts can expand the HSC population (Taichman & Emerson 1998), and depletion of osteoblasts leads to loss of hematopoietic tissue (Visnjic et al. 2004).”
• Rhythmic modulation of the hematopoietic niche through neutrophil clearance (2013, neutral): “Depletion of defined cellular niche elements, including CXCL12-abundant reticular cells (CAR cells), nestin+ mesenchymal progenitors or osteoblasts, result in egress of HSPC from the BM (Mendez-Ferrer et al., 2010; Omatsu et al., 2010; Visnjic et al., 2004).”