The Aedes aegypti Toll Pathway Controls Dengue Virus Infection
By Z. Xi, Jose L. Ramirez, G. Dimopoulos. PLoS Pathogens, 2008
842 citations recorded by the source corpus.
Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans. To date, the features of insects' innate immune defenses against viruses have mainly been studied in the fruit fly Drosophila melanogaster, which appears to utilize different immune pathways against different types of viruses, in addition to an RNA interference–based defense system. We have used the recently released whole-genome sequence of the Ae. aegypti mosquito, in combination with high-throughput gene expression and RNA interference (RNAi)-based reverse genetic analyses, to characterize its response to dengue virus infection in different body compartments. We have further addressed the impact of the mosquito's endogenous microbial flora on virus infection. Our findings indicate a significant role for the Toll pathway in regulating resistance to dengue virus, as indicated by an infection-responsive regulation and functional assessment of several Toll pathway–associated genes. We have also shown that the mosquito's natural microbiota play a role in modulating the dengue virus infection, possibly through basal-level stimulation of the Toll immune pathway.
Subfields: Immunology, Insect Science, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/7efabb4c0cb40530c54af6fd027c4ce987548ad1
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In Immunology
- Yuemei Dong
- Fabio Manfredini
- G. Dimopoulos
- Luís Teixeira
- Michael Ashburner
- Herbert W. Virgin
- Z. Xi
- Álvaro G A Ferreira
In Insect Science
- Yuemei Dong
- Fabio Manfredini
- G. Dimopoulos
- Luís Teixeira
- Michael Ashburner
- Z. Xi
- Álvaro G A Ferreira
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Implication of the Mosquito Midgut Microbiota in the Defense against Malaria Parasites (2009, methodology): “falciparum’s capacity to establish infection through the removal of bacteria with antibiotic treatment, according to the established methodology [24,25].”
- The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster (2008, background): “It was also reported recently that the presence of gut flora slightly increases the resistance of Aedes aegypti to Dengue virus, presumably through activation of the Toll pathway [60].”
- The Endosymbiotic Bacterium Wolbachia Induces Resistance to Dengue Virus in Aedes aegypti (2010, methodology): “egypti, we have further demonstrated that the anti-bacterial defense responses can control dengue infection [14].”
- A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium. (2009, methodology): “aegypti mosquitoes infected with dengue virus (Xi et al., 2008).”
- Virus-Plus-Susceptibility Gene Interaction Determines Crohn’s Disease Gene Atg16L1 Phenotypes in Intestine (2010, background): “There is also evidence for an intersection between viral infection and commensal bacteria (Brenchley et al., 2006; Xi et al., 2008).”