Recent advances in the innate immunity of invertebrate animals.

By S. Iwanaga, B. Lee. Journal of biochemistry and molecular biology, 2005

763 citations recorded by the source corpus.

Invertebrate animals, which lack adaptive immune systems, have developed other systems of biological host defense, so called innate immunity, that respond to common antigens on the cell surfaces of potential pathogens. During the past two decades, the molecular structures and functions of various defense components that participated in innate immune systems have been established in Arthropoda, such as, insects, the horseshoe crab, freshwater crayfish, and the protochordata ascidian. These defense molecules include phenoloxidases, clotting factors, complement factors, lectins, protease inhibitors, antimicrobial peptides, Toll receptors, and other humoral factors found mainly in hemolymph plasma and hemocytes. These components, which together compose the innate immune system, defend invertebrate from invading bacterial, fungal, and viral pathogens. This review describes the present status of our knowledge concerning such defensive molecules in invertebrates.

Subfields: Cellular and Molecular Neuroscience, Immunology

View Paper: https://www.semanticscholar.org/paper/9845a54672fa063dc307b855bc1659a366781e28

Citations in the corpus

• A Review of the Culture and Diseases of Redclaw Crayfish Cherax quadricarinatus (Von Martens 1868) (2013, neutral): “Crustaceans in general lack adaptive immune systems and rely solely on an innate immunity that defends invertebrates from invading bacterial, fungal, and viral pathogens (S¨oderh¨all and Cerenius 1998; Iwanaga and Lee 2005).”