The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis

By Junxian He, Joshua M. Gendron, Yanli Yang, Jianming Li, Zhi-Yong Wang. Proceedings of the National Academy of Sciences of the United States of America, 2002

654 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/cb9300e25e16b6b1bb70936652079ebe2cb5eb9f

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Citations in the corpus

Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis (2010, positive): “The transgenic plants accumulate the BZR1-CFP protein at a level similar to the endogenous BZR1 of wild-type plants, but the endogenous BZR1 protein at a much reduced level (Figure S1), presumably due to posttranslational control of total BZR1 protein level (He et al., 2002).”
Brassinosteroid signal transduction from cell surface receptor kinases to nuclear transcription factors (2009, neutral): “These include accelerating proteasome-mediated degradatio”
Interdependency of Brassinosteroid and Auxin Signaling in Arabidopsis (2004, background): “When BR levels are low, proteins in the BES1/ BZR1 family are hyperphosphorylated by BIN2 and targeted for degradation by the proteasome (He et al. 2002; Yin et al. 2002a).”
Brassinosteroid signal transduction from receptor kinases to transcription factors. (2010, background): “BR treatment induces rapid dephosphorylation of BZR1 and BZR2/BES1, which can be detected as band shift in immunoblotting (26, 93, 97).”
A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis. (2005, positive): “BZR1 is also similarly regulated by BIN2 kinase (He et al., 2002).”
The Regulation of Brassinosteroid Biosynthesis in Arabidopsis (2013, background): “Alternatively, phosphorylated BZR1 inside the nucleus binds inefficiently to the promoter DNA of its target genes (He et al., 2002).”
Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. (2003, background): “Thus, the down- stream positive regulators in the pathway are dere- two nuclear proteins BES1/BZR1 (He et al., 2002; Yin et al., 2002).”
Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses[OPEN] (2019, background): “Lastly, BES1 and BZR1 are regulated by multiple E3 ubiquitin ligases that control their degradation through the26Sproteasome or selective autophagy.”
Growth-defense tradeoffs in plants: a balancing act to optimize fitness. (2014, neutral): “In the absence of BR, the glycogen-synthase-kinase-3-like kinase BRASSINOSTEROID INSENSITIVE 2 (BIN2) phosphorylates two nuclear-localized transcription factors, BRI1-EMS-SUPPRESSOR 1 (BES1) and BRASSINAZOLE-RESISTANT 1 (BZR1), to block activation of BR-responsive genes (He et al., 2002; Wang et al.”