MAP kinase signalling pathways in cancer

By A. Dhillon, S. Hagan, Oliver Rath, Walter Kolch. Oncogene, 2007

2,956 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/cb6751ebebb8940fb6df4a27c7f4a3b5e5c2bde3

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Citations in the corpus

ERK1/2 MAP kinases: structure, function, and regulation. (2012, background): “The following enzyme forms have been described: ERK1–ERK8, p38 / / / , and JNK1–3 [5–7].”
Inflammatory responses and inflammation-associated diseases in organs (2015, background): “The mammalian MAPKs include extracellular-signal-regulated kinase ERK1/2, p38 MAP Kinase, and c-Jun N-terminal kinases (JNK) [33].”
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Activated ERK itself also translocates to the nucleus to activate ternary complex factor (TCF) transcription factors, which play a major role in the induction of immediate early genes (IEGs) [210].”
Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action (2010, background): “Furthermore, they may modulate the activity of signaling pathways [58-60] (i.”
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “372 RAFi adaptation to RAF dimerization: feedback inhibition and paradoxical activation in RAF-mutant cancers Aberrant ERK1/2 signaling can lead to oncogenicity, depending on the extent of ERK1/2 activation 373 .”
Regulation of PD-L1: a novel role of pro-survival signalling in cancer. (2016, background): “The MAPK signalling pathway plays a critical role in cell survival and proliferation [47-49].”
Matrix density-induced mechanoregulation of breast cell phenotype, signaling, and gene expression through a FAK-ERK linkage (2009, positive): “The ERK/mitogen-activated protein kinase (MAPK) pathway has been implicated in multiple cellular processes such as proliferation, migration and apoptosis (Dhillon et al., 2007; Turjanski et al., 2007; Yoon & Seger, 2006).”
Natural polyphenols: An overview (2017, background): “oxidoreductase, glutathione-S-transferase, and/or activity of the P450 enzyme, polyphenol can help detoxifying carcinogens([80]) and may also modulate the activity of signaling pathways([81,82]) that are involved in proliferation of cancer cells.([83,84]) Mitogen-activated protein kinases (MAPK) sig”
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. (2008, background): “Activation of MAPKs regulates cellular homeostasis and processes including proliferation, differentiation, and apoptosis.(87,88) ERK, p38, and JNK/SAPK are activated in various experimental models of cisplatin nephrotoxicity.”
The Ras-ERK and PI3K-mTOR Pathways: Cross-talk and Compensation (2011, background): “For example, ERK phosphorylates and inhibits SOS, Raf, and MEK1, thereby reducing ERK activation (Figure 1a, [4]).”
Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “The kinase Raf-1 is activated by the small GTPase Ras, whose activation is mediated by the receptor tyrosine kinase (RTK)-Grb2-SOS signaling axis [3].”
The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. (2011, background): “On the other hand, when dysregulated, this cascade plays a major role in various pathologies, inducing neurodegenerative diseases [21], developmental diseases [22], diabetes [23], and particularly notable — cancer [24,25].”