Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

By K. Cusi, K. Maezono, Abdullah A. Osman, Merri Pendergrass, M. Patti, T. Pratipanawatr, Ralph DeFronzo, C. Kahn, Lawrence J. Mandarino. Journal of Clinical Investigation, 2000

1,165 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/cb415e5882a5ebdd8e6253d9a08aa4da3c80b512

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Ralph DeFronzo

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Citations in the corpus

Cardiovascular actions of insulin. (2007, background): “A key feature of insulin resistance is that it is characterized by specific impairment in PI3K-dependent signaling pathways, whereas other insulin-signaling branches including Ras/MAPK-dependent pathways are unaffected (202, 203).”
Para-inflammation in the aging retina. (2009, background): “In diabetes, the phosphoinositide 3-kinase/Akt/ protein kinase B signalling pathway is significantly altered, resulting in a marked decrease of eNO synthase (eNOS) activation (Cusi et al., 2000).”
The metabolic syndrome. (2008, background): “24 h after the last bout of exercise (566).”
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus (2009, background): “Because the MAP kinase pathway retains its sensitivity to insulin (143,159,160), this causes excessive stimulation of this pathway and activation of multiple intracellular pathways involved in inflammation and atherogenesis.”
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009, background): “Molecular etiology of the skeletal muscle insulin resistance in genetically predisposed individuals Using the euglycemic insulin clamp with skeletal muscle biopsy, a number of investigators have examined the insulin signal transduction system in human skeletal muscle of type 2 diabetic subjects and ”
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 (2012, background): “In contrast with AKT, basal or insulin-stimulated ERK1/2 activation in diabetic muscle is unchanged or increased in several studies, compatible with its partial independence from IR/IRS [82, 86].”
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. (2004, methodology): “(35) in patients with type 2 diabetes and is consistent with the decrease in upstream signaling observed in obese subjects (26,27).”
Pathogenesis of type 2 diabetes mellitus. (2004, methodology): “Intact stimulation of the MAPK pathway by insulin in the presence of insulin resistance in the PI3K pathway may play an important role in the development of atherosclerosis [185].”