Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

By John M Adams, T. Pratipanawatr, R. Berria, E. Wang, Ralph DeFronzo, M. Sullards, Lawrence J. Mandarino. Diabetes, 2004

692 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3ff5145afdc7871ef7268b9cb9c6dc1bcc9c4d8e

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In Cognitive Neuroscience

Ralph DeFronzo

In Endocrine and Autonomic Systems

In Molecular Biology

Citations in the corpus

Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “Although TG accumulation in skeletal muscle and liver clearly correlates with insulin resistance, TG are generally perceived to be metabolically inert associates of more favored candidates which include long-chain acylcoenzyme A (LCCoAs), diacylglycerol (DAG) (46, 129), and ceramides (1).”
Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance (2009, background): “(8) demonstrated that the greatest increase in ceramide subspecies in obese subjects was for C16:0 and C20:0 (increased 76 and 83%, respectively).”
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus (2009, background): “Increased intramyocellular levels of diacylglycerol (194,211) and ceramides (212,213) have also been demonstrated in type 2 diabetic and obese nondiabetic subjects and shown to be related to the insulin resistance and impaired insulin signaling in muscle.”
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. (2007, background): “Supporting this conclusion are studies in rodents and humans indicating that ceramide inversely correlates with insulin sensitivity (Adams et al., 2004; Straczkowski et al., 2004) and that exercise decreases ceramide in concert with its beneficial effects on insulin action (Dobrzyn et al., 2004;…”
Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. (2009, background): “rodent and humans (5, 6), impairs the insulin-stimulated glucose”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “Indeed, there are mechanistic links between the development of insulin resistance and the accumulation of DAG and ceramide in muscle (8, 271, 272, 310), although, as put forward by Goodpaster and colleagues previously for triacyclyglycerol, a paradox for DAG in muscle of endurance-trained athletes i”
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009 (2010, background): “Muscle [150] and plasma [151] ceramide levels are also increased in obese and type 2 diabetic individuals, correlating closely with severity of insulin resistance.”