Protein dynamics: implications for nuclear architecture and gene expression.

By Tom Misteli. Science, 2001

675 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cb0ff29b2912c6afe129974ba48832577ffad62d

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In Molecular Biology

Citations in the corpus

Nuclear Pre-mRNA Splicing in Plants (2001, background): “Recent studies suggest that RNAs and RNA processing factors move by diffusion through interchromatin space (Lewis and Tollervey, 2000; Misteli, 2001).”
Beyond the sequence: cellular organization of genome function. (2007, positive): “However, given the ability of most nuclear proteins to rapidly roam the nucleus for specific binding sites, even relatively low-abundance proteins frequently encounter specific target sites (Misteli, 2001b).”
Nucleolar proteome dynamics (2005, methodology): “Recent light microscopy studies, analysing nuclear fluorescent fusion proteins using techniques such as fluorescence recovery after photobleaching (FRAP) or fluorescence loss in photobleaching (FLIP), have revealed the high mobility of many nuclear factors and their often rapid exchange between nucl”
Kinetics of Core Histones in Living Human Cells (2001, methodology): “Photobleaching techniques such as FRAP then permit analysis of diffusion coefficients, rates of exchange of tagged proteins between different cellular compartments, and the proportions of mobile and immobile fractions (Ellenberg and Lippincott-Schwartz, 1999; White and Stelzer, 1999; Misteli, 2001).”
Analysis of binding reactions by fluorescence recovery after photobleaching. (2004, background): “Although transient binding interactions are presumed to influence the FRAP recovery of a transcription factor (Misteli, 2001), little is known about what these binding interactions are.”
Estrogen-receptor-α exchange and chromatin dynamics are ligand- and domain-dependent (2006, background): “Collectively, the data support a stochastic model of nuclear function (Misteli, 2001; Vermeulen and Houtsmuller, 2002) because fast (and regulated) ER exhibits altered exchange rates at the chromosomally integrated PRL array.”
Nuclear speckles: a model for nuclear organelles (2003, background): “In recent years it has become apparent that the nucleus is highly compartmentalized but extremely dynamic (for reviews, see Ref”
Nuclear speckles. (2011, background): “Most evidence points to the fact that nuclear speckles form through a process of self-assembly (reviewed in Misteli 2001b) whereby transient macromolecular interactions form the basis of speckle morphogenesis.”
Cellular roles of DNA topoisomerases: a molecular perspective (2002, background): “The molecular nature of the observed differences between the effects of the DNA topoisomerases on transcription that is mediated by RNA polymerases I and II is unclear, but it might be related to the very robust expression of the ribosomal DNA gene cluster, or the organization of discrete substructu”
Controlling the double helix (2003, background): “Many, and probably most, chromatin-binding proteins are in continuous flux between association with chromatin and the nucleoplas”
Kinetic modelling approaches to in vivo imaging (2001, background): “It is important to realize that all photobleaching methods measure apparent mobilitie”