Nuclear speckles.

By David L. Spector, Angus I. Lamond. Cold Spring Harbor Perspectives in Biology, 2011

819 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1432043376042a2441e5e60d60114de4f40e9969

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Citations in the corpus

Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus (2018, background): “…are known to localize at nuclear speckles (Hutchinson et al., 2007), a nuclear body that contains proteins involved in mRNA splicing and processing (Spector and Lamond, 2011), we hypothesized that inter-chromosomal interactions occurring between regions in the active hub may be spatially organized…”
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “MALAT1 is a highly abundant nucleusrestricted RNA that localizes to nuclear speckles, a sub-nuclear domain suggested to coordinate RNA polymerase II transcription, pre-mRNA splicing and mRNA export [43,44,45].”
RNA Phase Transitions in Repeat Expansion Disorders (2017, neutral): “5), non-membranous bodies that are enriched in pre-mRNA splicing factors 30 .”
Phase separation in biology; functional organization of a higher order (2016, background): “This ability to respond to environmental cues may represent the mechanistic basis for the involvement of the membrane-less organelles discussed herein in stress sensing [2, 4, 9, 11, 13, 15].”
Complexity of the Alternative Splicing Landscape in Plants[C][W][OPEN] (2013, background): “These two proteins are controlled by the circadian clock, and their protein levels are regulated similarly to PTBs by AS and the production of NMDsensitive transcripts (Carpenter et al., 1994; Heintzen et al., 1994; Staiger, 2001; Staiger et al., 2003).”
The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. (2013, background): “These structures are regions enriched in premRNA splicing factors and could serve as storage, assembly, or modification sites (21).”
Biogenesis and Function of Nuclear Bodies (2011, background): “However, proteins other than pre-mRNA splicing factors, such as some transcription factors, serine 2 phosphorylated RNA Pol II, and components of the transcription elongation complex have also been shown to localize in speckles [67].”