Nuclear speckles: a model for nuclear organelles

By Angus I. Lamond, David L. Spector. Nature reviews. Molecular cell biology, 2003

1,035 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/da3a340598ac526fc5e1f4555f645cbcbc7e89a4

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Citations in the corpus

Regulating gene expression through RNA nuclear retention. (2005, background): “Persistent activation of NOS2 can lead to the production of toxic levels of NO, resulting in several diseases, including multiple sclerosis, Huntington’s disease, and Parkinson’s disease (Lee et al., 2003).”
An Architectural Role for a Nuclear Non-coding RNA: NEAT1 RNA is Essential for the Structure of Paraspeckles (2009, background): “There are now known to be many discrete nuclear compartments or bodies that produce a spotted or ‘‘speckled’’ appearance; these are distinguished by the subsets of factors they contain and are implicated in different aspects of nuclear function (Hall et al., 2006; Lamond and Spector, 2003; Misteli, ”
The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation (2010, background): “Nuclear speckles are highly dynamic subnuclear domains enriched with pre-mRNA splicing/processing factors (Hall et al., 2006; Lamond and Spector, 2003).”
AU-rich elements and associated factors: are there unifying principles? (2006, background): “The co-localization of transcribed genes in the nucleus is now being documented (147) and the nuclear processing (capping, splicing and polyadenylation) of pre-mRNAs is also coordinated within particles [reviewed in (148,149)].”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Moreover, the lipid PtdIns(4,5)P2 itself could be localized by antibodies or by PtdIns(4,5)P2 recognizing PH domains in the nuclear matrix, especially enriched in nuclear speckles (1087, 1176, 1684), the dynamic organelles that have high pre-mRNA splicing activity (849).”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “…Lin et al. 2007) and was shown previously to be retained specifically in the nucleus in nuclear speckles (Hutchinson et al. 2007), domains that are thought to be involved in the assembly, modification, and/or storage of the premRNA processing machinery (for review, see Lamond and Spector 2003).”
Phase separation in biology; functional organization of a higher order (2016, background): “cent to nucleoplasmic interchromatin regions [3], nuclear speckles, also referred to as snurposomes, are a distinct class of dynamic organelles [1].”
Beyond the sequence: cellular organization of genome function. (2007, positive): “In addition to the complex arrangement of the genetic information itself, the cellular factors that read, copy, and maintain the genome are organized in sophisticated patterns within the cell nucleus (Lamond and Spector, 2003; Misteli, 2005).”
A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains (2007, background): “Much debate has centered on the function and composition of these domains, either as sites of pre-mRNA metabolism and export [1012] or storage sites of splicing factors [8,13].”