Cellular roles of DNA topoisomerases: a molecular perspective

By James C. Wang. Nature reviews. Molecular cell biology, 2002

2,336 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0799d5f1c41d712fa8231cf3b235fb71324f7efa

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Citations in the corpus

Maintaining genome stability at the replication fork (2010, background): “Therefore, this tension can only be altered by DNA breakage and reunion reactions, which are mediated by specialized DNA nucleases called topoisomerase”
Regulation of DNA repair throughout the cell cycle (2008, background): “The connections between DNA repair and other chromosome-metabolism processes, such as replication, transcription, cohesion and condensation, segregation, and DNA topology, have been discussed in other review”
The General Transcription Machinery and General Cofactors (2006, background): “This protein is well known for its role in relaxing DNA by transiently introducing nicks, allowing strand passage and religation (Wang, 2002).”
DNA topoisomerase II and its growing repertoire of biological functions (2009, neutral): “An important model for generation of supercoiling during transcription has been described by Liu and Wang, and posits that the tracking of RNA polymerase leads to transient positive supercoiling ahead of the transcriptional machinery and negative supercoiling behind it; the generation of supercoils ”
Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage (2005, background): “BLM functions in association with topoisomerase III (Top3 ) (68), a type I class of topoisomerases (11, 37, 67, 69).”
Single-strand break repair and genetic disease (2008, neutral): “TOP1 creates a 'cleavage complex' intermediate containing a DNA nick in order to relax DNA during transcription and DNA replicatio”
Anthracycline Chemotherapy and Cardiotoxicity (2017, background): “Conversely, Top2β is more abundant in quiescent cells, such as adult mammalian cardiomyocytes, and its expression remains constant throughout the cell cycle.”