Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite

By K. Spiegel, Esra Tasali, P. Penev, E. Cauter. Annals of Internal Medicine, 2004

2,464 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/caf26bffc40054205a31a17d32c82ebe9d90b8cc

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In Cognitive Neuroscience

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Citations in the corpus

The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Because the circadian clock is so intimately linked to cellular metabolism and cell proliferation, new therapeutic indications such as predisposition to type 2 diabetes and obesity might become amenable to treatments that modulate the circadian and sleep system”
Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load. (2006, background): “Sleep restriction to 4 hours of sleep per night increases blood pressure, decreases parasympathetic tone, increases evening cortisol and insulin levels, and promotes increased appetite, possibly through the elevation of ghrelin, a pro-appetitive hormone, and decrease in levels of leptin [15-17].”
Pathophysiology of human visceral obesity: an update. (2013, neutral): “increase susceptibility to visceral fat deposition (526).”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “Appetite for energy-dense, high-carbohydrate foods showed the greatest increase (Spiegel et al., 2004b).”
Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain (2013, background): “This may help to explain why leptin levels are lower and ghrelin levels are higher in prior sleep loss studies that controlled food intake (18, 19).”
Short Sleep Duration and Weight Gain: A Systematic Review (2008, background): “Comparing 4 h of sleep opportunity per night to 10 h over a period of 2 days, both hunger and appetite scores on a visual analog scale were elevated by sleep deprivation (4).”
Cardiovascular, Inflammatory and Metabolic Consequences of Sleep Deprivation (2009, background): “Leptin, an adipocyte hormone that signals satiety to the brain, is reduced in diurnal rhythm amplitude (28) and peak amount (29) as measured in peripheral circulation during acute total and sustained partial sleep deprivation.”
Sleep curtailment is accompanied by increased intake of calories from snacks (2008, background): “In addition, lower leptin and higher ghrelin concentrations and increased hunger and appetite have been reported after short-term sleep restriction of healthy men (10).”