Sirt1 protects against high-fat diet-induced metabolic damage

By P. Pfluger, D. Herranz, S. Velasco-Miguel, Manuel Serrano, Matthias Tschöp. Proceedings of the National Academy of Sciences of the United States of America, 2008

954 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/cad550fae7d71109ad26aeab08b2302ab81fd8d2

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Citations in the corpus

The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity (2012, neutral): “For example, SIRT1 transgenics show similar body weight gain upon HFD to wild-type littermates (Pfluger et al., 2008).”
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. (2013, background): “, 2007) or preventive effects on metabolic complications caused by high-fat diet and aging (Banks et al., 2008; Pfluger et al., 2008).”
AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol (2009, background): “More recently, transgenic mice in which the Sirt1 transgene is expressed from its own promoter have been reported by two independent groups (35,37).”
Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “Additionally, recent studies demonstrated that modest overexpression of SIRT1 resulted in a protective effect against high-fat induced hepatic steatosis and glucose intolerance (Banks et al., 2008; Pfluger et al., 2008).”
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “…many of the salutary effects of CR, including a reduced incidence of cardiovascular and metabolic diseases (Banks et al., 2008; Bordone et al., 2007; Pfluger et al., 2008), cancer (Herranz et al., 2010; Oberdoerffer et al., 2008), and neurodegeneration (Donmez et al., 2010; Qin et al., 2006).”
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, neutral): “, 2004), overexpression of Sirt1, the mammalian homolog of Sir2, has been reported to protect mice from aging-related phenotypes that are similar to type 2 diabetes (Banks et al., 2008; Bordone et al., 2007; Pfluger et al., 2008), cancer (Herranz et al.”
NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “carbazole chemical P7C3 (Pieper et al., 2010), which was only recently discovered to be a pharmacological activator of NAMPT (Wang et al.”
Sirtuins as regulators of metabolism and healthspan (2012, background): “This notion is supported by the fact that Sirt1 -overexpressing mice are protected from hepatic steatosi”
From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, background): “Sirtuins 1, 2, and 3 prolong lifespan; improve energy expenditure, glucose production, and insulin sensitivity; and protect against high-fat dietinduced metabolic damage via several mechanisms, including the deacetylation of FoxOs and modulation of FoxO-mediated transcription (328).”