Interleukin 4 inhibits TGF-β-induced-Foxp3+T cells and generates, in combination with TGF-β, Foxp3− effector T cells that produce interleukins 9 and 10

By V. Dardalhon, A. Awasthi, H. Kwon, George Galileos, Wenda Gao, R. Sobel, M. Mitsdoerffer, T. Strom, W. Elyaman, I. Ho and 3 more. Nature Immunology, 2008

1,005 citations recorded by the source corpus.

Transcription factor Foxp3 is critical for generating regulatory T cells (Treg cells). Transforming growth factor-β (TGF-β) induces Foxp3 and suppressive Treg cells from naive T cells, whereas interleukin 6 (IL-6) inhibits the generation of inducible Treg cells. Here we show that IL-4 blocked the generation of TGF-β-induced Foxp3+ Treg cells and instead induced a population of T helper cells that produced IL-9 and IL-10. The IL-9+IL-10+ T cells demonstrated no regulatory properties despite producing abundant IL-10. Adoptive transfer of IL-9+IL-10+ T cells into recombination-activating gene 1–deficient mice induced colitis and peripheral neuritis, the severity of which was aggravated if the IL-9+IL-10+ T cells were transferred with CD45RBhi CD4+ effector T cells. Thus IL-9+IL-10+ T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/5499aac835e2666c0f64105d3e6e20cecd6b2458

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In Immunology

1. Jinfang Zhu
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Citations in the corpus

• Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “Furthermore, our unpublished data indicate that GATA3 is required for the induction of IL-9-producing cells, although it is expressed at lower levels in Th9 cells than that in Th2 cells.”