HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

By H. Yanai, T. Ban, Zhichao Wang, M. Choi, T. Kawamura, Hideo Negishi, M. Nakasato, Yan Lu, S. Hangai, Ryuji Koshiba and 8 more. Nature, 2009

719 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/ca042d3d31704fffc447fd5b6ada1eb1e672b1d2

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Citations in the corpus

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection (2011, background): “It has been known for decades that HMGB1 can facilitate cellular uptake of DNA, and recent evidence has placed this mechanism into the context of inflammation (28).”
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus (2011, background): “3A), a protein that functions as a universal sentinel for nucleic acids and leads to type I IFN and inflammatory cytokine secretion by targeting DNA or RNA to cytosolic nucleic acid–sensing receptors (26).”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Indeed, HMGB family members function as universal sentinels for nucleic acids in innate immune signaling (79).”
Sepsis: current dogma and new perspectives. (2014, background): “As a universal sentinel for infection or injury, HMGB1 appears as a delayed mediator after the onset of infection and serum concentrations might remain elevated in survivors—for up to 30 days in mice, and even longer in humans (Chavan et al., 2012; Yanai et al., 2012; Yanai et al., 2009).”
The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, background): “In this regard, highly conserved molecules that bind to nucleic acids, such as HMGB1, are potentially important in modulating the ability of nucleic acids to activate innat”
Phagocyte partnership during the onset and resolution of inflammation (2010, background): “We now know that complexes between HMGB1 and DAMPs (such as single-stranded DNA, LPS or nucleosomes) interact with the canonical HMGB1 receptor RAGE (receptor for advanced glycation end products) as well as TLR2 , TLR4, TLR9 and IL-1R to induce cytokine productio”
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors (2014, background): “Chaperoning of tumor-derived DNA by high-mobility group box 1 (HMGB1) is another potential mechanism (Yanai et al., 2009), which based on our results would likely be via a TLR-independent fashion.”
Cytosolic Sensing of Viruses (2013, background): “LRRFIP1, HMGB proteins, and ABCF1 (ATP-binding cassette, subfamily F member 1) have also been shown to bind DNA directly and positively regulate IFN responses (Lee et al., 2013; Yanai et al., 2009; Yang et al., 2010).”
Endogenous HMGB1 regulates autophagy (2010, background): “, 2008), and its critical role as a universal DNA sensor (Yanai et al., 2009; Sims et al., 2010), we propose a more nuanced conceptual model involving HMGB1 and cell death.”