Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

By D. Moshous, I. Callebaut, R. de Chasseval, B. Corneo, M. Cavazzana‐Calvo, F. Le Deist, I. Tezcan, O. Sanal, Y. Bertrand, N. Philippe and 2 more. Cell, 2001

908 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c9ee8925f407d802a32d175673b4e01f207ed112

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In Epidemiology

1. F. Alt
2. David H. Jung

In Immunology

1. Yosef Shiloh
2. M. Lieber
3. F. Alt
4. David H. Jung

In Molecular Biology

1. M. Lieber
2. B. Kaina
3. W. Roos
4. P. Jeggo
5. M. O’Driscoll
6. Yosef Shiloh
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8. Mengyuan Huang

Citations in the corpus

• Mechanism and regulation of human non-homologous DNA end-joining (2003, background): “pl?Q96SD1"> ARTEMIS , was identified on the basis of its mutation in patients with human severe combined immunodeficiency (SCID”
• Mechanisms of human DNA repair: an update. (2003, background): “DNA–PK activates XRCC4–ligase IV, which links the broken DNA ends together .”
• Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects (2020, background): “The identification of novel small molecule inhibitors against other NHEJ proteins, such as artemis and XRCC4, may further advance current strategies.(307,308) An improved CRISPR system, called CRISPR/Cpf1 or CRISPR/Cas12a, that employs a smaller and simpler RNA-guided DNA nuclease, Applications of g”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, neutral): “1999; Jensen et al. 2000; Moshous et al. 2001; Hald et al. 2003; Murtaugh et al. 2003).”
• The role of double-strand break repair — insights from human genetics (2006, background): “Artemis belongs to a sub-group (the β-CASP family) of the metallo-β-lactamase superfamil”
• Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. (2006, positive): “V(D)J recombination on extra chromosomal substrates was performed as previously described using full-length human Rag1 and Rag2 (Nicolas et al., 1998; Moshous et al., 2001).”
• ATM and related protein kinases: safeguarding genome integrity (2003, background): “Loss of Artemis in humans causes SCID and radiation sensitivit”