Mechanism and regulation of human non-homologous DNA end-joining

By M. Lieber, Yunmei Ma, U. Pannicke, K. Schwarz. Nature reviews. Molecular cell biology, 2003

1,034 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d2152a5594a12362dc44cbb7dc4b2f40d87948b8

How researchers see this paper

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In Molecular Biology

1. Feng Zhang
2. W. Gu
3. M. Lieber
4. J. R. Lupski
5. K. Gudmundsdottir
6. Alan Ashworth
7. Christian Staudt
8. G. Iliakis

In Oncology

1. K. Gudmundsdottir
2. Alan Ashworth
3. M. Lieber
4. Mark J. O'Connor

Citations in the corpus

• Mechanism and regulation of class switch recombination. (2008, background): “Ku70–Ku80 binds DNA ends at DSBs and telomeres and mediates synapsis of the two DNA ends, positioning the ends to allow end processing and direct end-to-end joining (174, 175).”
• Human and chimpanzee Luteinizing hormone/ Chorionic Gonadotropin beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes (2009, background): “Gene conversion mediates the transfer of genetic information from intact homologous sequence to the region that contains the DSB, and it can occur between sister chromatids, homologous chromosomes or homologous sequences on either the same chromatid or different chromosomes.”
• The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability (2006, background): “In NHEJ, the initial event involves the binding of the Ku70/Ku80 heterodimer to broken DNA ends (Lieber et al., 2003; Hefferin and Tomkinson, 2005).”
• Mechanisms for human genomic rearrangements (2008, background): “Some simple non-recurrent rearrangements can occur via NHEJ NHEJ is one of the two major mechanisms used by eukaryotic cells to repair DSB and has been described in organisms from bacteria to mammals [66-68].”
• The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway (2010, background): “Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma.”
• γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “ligase IV/XRCC4/XLF complex to mediate end-ligation possibly with the help of a DNA polymerase that catalyzes gap filling (19,149,150).”