Hippocampal Neurogenesis is not Required for Behavioral Effects of Environmental Enrichment.

By G. Mckhann. 2006

302 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “However, it is currently debated whether hippocampal neurogenesis is necessary for these behavioural effects of environmental enrichmen”
Enriched environments, experience-dependent plasticity and disorders of the nervous system (2006, background): “Enrichment-induced enhancement of learning and memory might relate to cellular effects on synaptic plasticity and hippocampal neurogenesis, although a recent study suggests that increased hippocampal cell proliferation is not necessary for improved spatial memory performanc”
Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment (2006, background): “A recent paper demonstrates that hippocampal neurogenesis is not required for the behavioural effects of environmental enrichment (Meshi et al., 2006).”
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain (2009, background): “However, whether there is a causal relationship between neurogenesis and cognition is currently under debate (Meshi et al., 2006), and results from studies of the causal relationship between hippocampal neurogenesis and cognition are inconsistent and sometimes contradictory (for review, see Zhao et…”
Experience dictates stem cell fate in the adult hippocampus. (2011, unknown): “…24 hr (n = 3), 48 hr (n = 5), 5 days (n = 3), 2 weeks (n = 2), 1 month (n = 3, 4), 3 months (n = 3), 6 months (n = 3), or 12 months (n = 6) after the first day of TMX. EEE conditions have been previously described (Meshi et al., 2006); however, animals were housed six to an enriched cage.”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, methodology): “Whereas some studies found no impairment www.learnmem.org 151 Learning & Memory in the water maze (using irradiation and MAM) (Shors et al. 2002; Meshi et al. 2006), others described substantial deficits in longterm retention (using irradiation [Snyder et al. 2005] or diphtheria toxin-based…”
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory (2009, background): “Only the hippocampal region was exposed to gamma rays, while other brain regions were shielded from irradiation [17,18].”
Adult hippocampal neurogenesis in depression (2007, background): “Beneficial effects of environmental enrichment and exercise on learning and on anxiety-like behavior can occur independently of increased adult hippocampal neurogenesi”
Mechanisms and functional implications of adult neurogenesis. (2008, unknown): “Furthermore, many other studies were not able to detect any defects in spatial learning in animals with reduced or abolished neurogenesis (Madsen et al., 2003; Meshi et al., 2006; Saxe et al., 2006; Shors et al., 2002; Snyder et al., 2005), despite the fact that impaired long-term retention of memor”
Experience-Specific Functional Modification of the Dentate Gyrus through Adult Neurogenesis: A Critical Period during an Immature Stage (2007, result): “This finding is consistent with reports that, in some forms of hippocampusdependent task, not short-term (Meshi et al., 2006) but longterm memory is dependent on adult neurogenesis (BruelJungerman et al., 2005; Snyder et al., 2005).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “neurogenesis is not necessary for the behavioral effects of environmental enrichment (Meshi et al., 2006).”
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “…input is consistent with a loss of young adult-generated neurons after X-irradiation, since these neurons have been shown to be more highly excitable and subject to weaker inhibition than mature granule cells (Doetsch and Hen, 2005; Esposito et al., 2005; Ge et al., 2008; Mongiat et al., 2009).”