Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory

By H. Ko, Deok‐Jin Jang, Junehee Son, Chuljung Kwak, Jun-Hyeok Choi, Young-Hoon Ji, Yun-Sil Lee, Hyeon Son, B. Kaang. 2009

140 citations recorded by the source corpus.

Newborn neurons in the subgranular zone (SGZ) of the hippocampus incorporate into the dentate gyrus and mature. Numerous studies have focused on hippocampal neurogenesis because of its importance in learning and memory. However, it is largely unknown whether hippocampal neurogenesis is involved in memory extinction per se. Here, we sought to examine the possibility that hippocampal neurogenesis may play a critical role in the formation and extinction of hippocampus-dependent contextual fear memory. By methylazoxymethanol acetate (MAM) or gamma-ray irradiation, hippocampal neurogenesis was impaired in adult mice. Under our experimental conditions, only a severe impairment of hippocampal neurogenesis inhibited the formation of contextual fear memory. However, the extinction of contextual fear memory was not affected. These results suggest that although adult newborn neurons contribute to contextual fear memory, they may not be involved in the extinction or erasure of hippocampus-dependent contextual fear memory.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

Citations in the corpus

• Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “Context-dependent memory, and specifically performance in contextual fear conditioning tasks, was also found to depend on neurogenesis (Ko et al., 2009; Saxe et al., 2006; Tronel et al., 2012).”