ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression.

By Jing-ming Zhang, Huikun Wang, Chang-quan Ye, Woo-ping Ge, Yiren Chen, Zhenglin Jiang, Chien-ping Wu, Mu-Ming Poo, S. Duan. Neuron, 2003

612 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/c9706091d0200e643de482dea555e8780e8366f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Neurology

In Physiology

Citations in the corpus

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo (2006, background): “In addition to perpetuating astrocytic Ca 2+ waves, ATP following hydrolysis to adenosine controls hippocampal network activit”
Astrocyte roles in traumatic brain injury (2015, background): “In healthy CNS tissue, astrocytes perform diverse functions critical for the function of mature neural circuits (Zhang et al., 2003; Schummers et al., 2008; Allen et al., 2012).”
Glia-derived D-serine controls NMDA receptor activity and synaptic memory. (2006, background): “…signaling are generally considered to be glutamate (Angulo et al., 2004; Fellin et al., 2004) or ATP (Gordon et al., 2005; Newman, 2003; Zhang et al., 2003), it is now obvious that another important gliotransmitter is the amino acid D-serine (Mothet et al., 2000), which serves as a…”
Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation (2007, background): “Astrocyte-released ATP and tumor necrosis factor- have also been shown to fine-tune synaptic ac- tivity by inhibiting glutamate release (Zhang et al., 2003) and modulating the expression of AMPA receptors (Beattie et al., 2002), respectively.”
Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate (2004, background): “or on the stimulation of astrocyte surface receptors, for example by neurotransmitters released during synaptic activit”
Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice (2013, background): “Astrocytes release ATP, which, after degradation to adenosine by extracellular ectonucleotidases, can suppress both basal synaptic transmission and activitydependent increases in synaptic strength (Pascual et al., 2005; Zhang et al., 2003).”
Gliotransmitters Travel in Time and Space (2014, positive): “As a result of this astrocyte modulatory action, synaptic transmission (solid blue line) can be either potentiated (Navarrete and Araque, 2010) or depressed (Zhang et al., 2003; Pascual et al., 2005; Andersson et al., 2007; Serrano et al., 2006) (dashed blue line in a and b, respectively).”
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, methodology): “Finally, FAC has been successfully used to specifically abolish astrocytes to neuron communication (44, 56, 76).”
Astrocyte control of synaptic transmission and neurovascular coupling. (2006, methodology): “(235), this study utilized fluorocitrate as a glial metabolic poison.”
Synaptic Islands Defined by the Territory of a Single Astrocyte (2007, background): “The astrocytic release of ATP (Arcuino et al., 2002) causes a presynaptic inhibition of excitatory synaptic transmission, an action that is mediated by adenosine, which accumulates after the hydrolysis of released ATP (Zhang et al., 2003; Pascual et al., 2005; Serrano et al., 2006).”