Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate
By P. Bezzi, V. Gundersen, J. Galbete, Gerald Seifert, C. Steinhäuser, E. Pilati, Andrea Volterra. Nature Neuroscience, 2004
738 citations recorded by the source corpus.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2a0b415cd0e767b7d0e2ab7d453a822b7131fcd1
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In Cellular and Molecular Neuroscience
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In Molecular Biology
Citations in the corpus
- The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. (2006, background): “Another source of glutamate release is the astrocyte, through a Caregulated exocytosis-like process (Bezzi et al., 2004).”
- Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “These data lend further support to the notion that the glutamate released from astrocytes selectively acts on extrasynaptic NMDARs that contain the NR2B subunit, an observation which is supported by the results of doublelabel immunoelectron microscopy (20) (Fig.”
- Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. (2004, positive): “…SICs, our results are compatible with the recent demonstration that astro-neurons; (2) stimulation of SCs, which evokes [Ca2 ]i oscillations in astrocytes (Pasti et al., 1997), also triggers cytes possess a mechanism for a regulated, vesicular release of this transmitter (Bezzi et al., 2004).”
- Glutamate exocytosis from astrocytes controls synaptic strength (2007, background): “Recently, the direct observation of exocytic fusions of glutamatergic vesicles in cultured astrocyte”
- Physiology of Astroglia. (2018, neutral): “All three types of vesicular glutamate transporters (VGLUT1–2/SLC17A6–8) have been identified in astrocytes in culture (169, 368, 529, 902, 1144).”
- Do astrocytes really exocytose neurotransmitters? (2010, neutral): “Astrocytes in situ in the hippocampus have been found by electron microscopy to contain small (∼30 nm) vesicles resembling those at synapse”
- Astrocytes, from brain glue to communication elements: the revolution continues (2005, background): “Recently, however, a clear synaptic-like microvesicle (SLMV) compartment, which is equipped for the uptake, storage and release of glutamate, has been identified in adult hippocampal astrocytes, and Ca 2+ -dependent exocytotic fusion has been documented in astrocyte cultures by total internal reflec”