Gliotransmitters Travel in Time and Space

By A. Araque, Giorgio Carmignoto, Philip Haydon, Stephane Oliet, R. Robitaille, Andrea Volterra. Neuron, 2014

1,178 citations recorded by the source corpus.

The identification of the presence of active signaling between astrocytes and neurons in a process termed gliotransmission has caused a paradigm shift in our thinking about brain function. However, we are still in the early days of the conceptualization of how astrocytes influence synapses, neurons, networks and ultimately behavior. In this review, our goal is to identify emerging principles governing gliotransmission and consider the specific properties of this process that endow the astrocyte with unique functions in brain signal integration. We develop and present hypotheses aimed at reconciling confounding reports and define open questions to provide a conceptual framework for future studies. We propose that astrocytes mainly signals through high affinity slowly-desensitizing receptors to modulate neurons and perform integration in spatio-temporal domains complementary to those of neurons.

Subfields: Biochemistry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/5276c2e022b5f2fe77d0690fafc3d78419aaee11

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In Cellular and Molecular Neuroscience

Citations in the corpus

Astrocytes: Orchestrating synaptic plasticity? (2015, neutral): “LTD!induction!moves!based!on!prior! activity!”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “Studies have since shown that mammalian cells can be reprogrammed in vivo, either by molecular or environmental factors, to exhibit expanded potentials that are not seen under physiological conditions (Arlotta and Berninger, 2014).”