Synaptic Islands Defined by the Territory of a Single Astrocyte

By Michael M. Halassa, Tommaso Fellin, H. Takano, Jinghui Dong, Philip Haydon. Journal of Neuroscience, 2007

727 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/04b3636afd4b29a831ab07041876982992e48d06

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “Reproduced with permission from Halassa et al. (2007).”
Astrocytes are endogenous regulators of basal transmission at central synapses. (2011, neutral): “Because astrocytes occupy exclusive domains within which they interact with several types of synapses (Bushong et al., 2002; Halassa et al., 2007), it is likely that they interact with and differentially modulate many synapses according to specific conditions driven by the various types of synapses.”
Astroglial networks: a step further in neuroglial and gliovascular interactions (2010, background): “Recently, morphological analysis of dye-filled astrocytes in the hippocampus and the cortex indicated that they are more 'spongiform' than star-shaped and occupy separate anatomical domain”
Regulation of synaptic connectivity by glia (2010, background): “The processes of protoplasmic astrocytes infiltrate into the neuropil and wrap themselves around synapse”
Astrocytes Control Synapse Formation, Function, and Elimination (2015, positive): “Detailed quantification of astrocyte domains in mice revealed that one cortical astrocyte enwraps multiple neuronal cell bodies and up to 600 dendrites and, through the finer processes, one astrocyte contacts 100,000 synapses (Halassa et al. 2007).”
Gliotransmitters Travel in Time and Space (2014, neutral): “Astrocyte Domains and Spatial Extent of Neuromodulation It is well established that each astrocyte occupies a determined volume that defines an exclusive astrocytic territory (Bushong et al., 2002; Halassa et al., 2007).”
Physiology of Astroglia. (2018, neutral): “A single protoplasmic astrocyte in the rodent cortex contacts 4 8 neurons, surrounds ~300 600 neuronal dendrites, and provides cover for up to 20,000 120,000 synapses residing within its domain (264, 627).”
Glial regulation of the cerebral microvasculature (2007, background): “One aspect of glial biology is that gray matter astrocytes extend over nonoverlapping spatial domain”
Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. (2012, background): “Tiling the entire brain in contiguous, orderly fashion, each single gray matter astrocyte has been estimated to envelope as many as 100,000 synapses (Halassa et al. 2007).”
Balancing structure and function at hippocampal dendritic spines. (2008, background): “Astroglia form nonoverlapping domains in the hippocampus and cortex, and a single astrocyte contacts hundreds of dendrites and thousands of synapses, which suggests that it coordinates multiple neuronal networks (Bushong et al. 2002, Halassa et al. 2007).”
Uniquely hominid features of adult human astrocytes (2009, background): “Human protoplasmic astrocytes are organized in domains Rodent protoplasmic astrocytes are organized into domains (Bushong et al., 2002; Ogata and Kosaka, 2002; Halassa et al., 2007).”