Glia-derived D-serine controls NMDA receptor activity and synaptic memory.

By Aude Panatier, D. Theodosis, J. Mothet, B. Touquet, L. Pollegioni, D. Poulain, Stephane Oliet. Cell, 2006

902 citations recorded by the source corpus.

Subfields: Biochemistry, Biological Psychiatry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/86730933dd63bc586411c04e5ce08f12d26092ea

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Citations in the corpus

Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “D-Serine is more potent than L-serine and may be the primary ligand for GluN1 in regions such as the supraoptic nucleus (e.g., Panatier et al., 2006).”
Handbook of ion channels (2015, background): “Ambient d-Ser, and that released by astrocytes (Panatier et al., 2006), rather than glycine, may be the physiological activator of native NMDA receptors (Schell et al.”
Glutamate exocytosis from astrocytes controls synaptic strength (2007, background): “We cannot, however, rule out the possibility that additional agents, such as the NMDA coagonist D -serin”
Gliotransmitters Travel in Time and Space (2014, positive): “Such glia-derived transmitters have been shown to act on neurons in timescales ranging from seconds to minutes and to regulate synaptic transmission and plasticity through a wide variety of mechanisms (Araque et al., 1999b; Bezzi et al., 1998; Brockhaus and Deitmer, 2002; Henneberger et al., 2010; J”
Matching Recall and Storage in Sequence Learning with Spiking Neural Networks (2013, background): “Unlike what is suggested by Panatier et al. (2006), this type of sliding threshold (r (t) in our case) is conceptually different from the one in the BCM learning rule (Bienenstock et al., 1982) since it is a global quantity whereas in the BCM learning rule the sliding threshold is a local quantity…”
Synaptic Islands Defined by the Territory of a Single Astrocyte (2007, background): “…which influence neuronal excitability and synaptic transmission: glutamate (Parpura et al., 1994; Bezzi et al., 1998) controls synaptic strength (Fiacco and McCarthy, 2004; Kang et al., 1998; Liu et al., 2004), whereas D-serine (Schell et al., 1995) regulates metaplasticity (Panatier et al., 2006).”
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. (2012, background): “…of NMDAR at several CNS synapses, such as the hippocampus (Henneberger et al., 2010; Mothet et al., 2000; Schell et al., 1995; Yang et al., 2003) the hypothalamus (Panatier et al., 2006), the cortex (Fossat et al., 2012), the retina (Stevens et al., 2010), and the spinal cord (Wake et al., 2001).”
The mystery and magic of glia: a perspective on their roles in health and disease. (2008, background): “Perhaps the most interesting of these is D-serine, an important neurotransmitter that serves as a coagonist with glutamate at NMDA receptors (Mustafa et al., 2004; Panatier et al., 2006).”
Astrocyte-neuron lactate transport is required for long-term memory formation (2011, positive): “These findings add to the evidence provided by a number of other studies that investigated other types of astrocytic mechanisms, including release of D-Serine (Henneberger et al., 2010; Panatier et al., 2006; Zhang et al., 2008), ATP-dependent vesicular release of glutamate (Jourdain et al.”
Astrocytes are endogenous regulators of basal transmission at central synapses. (2011, positive): “Integrated Presynaptic and Glial Mechanisms The regulatory role of astrocytes in basal synaptic transmission may be relevant to many other types of synapses in the CNS because they regulate synaptic transmission and plasticity in numerous brain areas (Gordon et al., 2009; Gourine et al., 2010; Matsu”