Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

By Heather L. Cash, Cecilia V Whitham, Cassie L. Behrendt, L. Hooper. Science, 2006

1,441 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/c92e89d44739dcc1c0e0065a6fd3c68c28b9cebf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Dan R. Littman
2. K. Honda
3. Y. Belkaid
4. D. Cua
5. J. Walter
6. C. Tato
7. Wenjun Ouyang
8. T. Hand

In Microbiology

1. A. Macpherson
2. K. Honda
3. B. B. Finlay
4. Frederick M. Ausubel
5. K. Takeda
6. D. Cua
7. Y. Belkaid
8. H. Wexler

Citations in the corpus

• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, methodology): “–induced genes were identified using filter microarray analysis of a subset of the genome; three of these genes had homology to C-type lectins, which have recently been shown to have antibacterial activity and are induced by bacterial exposure in mice [”
• Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “These proteins include defensins, cathelicidins, Reg family proteins, and ribonucleases (Cash et al., 2006).”
• Induction of intestinal Th17 cells by segmented filamentous bacteria (2009, background): “, 2006), but they also have profound effects on the host immune system (Cash et al., 2006; Macpherson and Harris, 2004).”
• Pathological bacterial translocation in liver cirrhosis. (2014, background): “200 Journal of Hepatology 201 peptidoglycans of gram-positive bacteria and function as bactericidal proteins even at low micromolar concentrations [54,55].”
• Bacteroides: the Good, the Bad, and the Nitty-Gritty (2007, background): “thetaiotomicron can induce Paneth cells to produce a bactericidal lectin, RegIII , which exerts its antimicrobial effect by binding to the peptidoglycan of gram-positive organisms (53).”
• Brain–Gut–Microbe Communication in Health and Disease (2011, background): “They are known to express and release a wide variety of antimicrobial peptides including α-defensins and lysozyme C. but require a complete microbiome to realize a full complement of these peptides (Hooper et al., 2003; Cash et al., 2006; Vaishnava et al., 2008).”
• Homeostatic immunity and the microbiota (2017, neutral): “Production of this lectin is tightly controlled by the flora in a MyD88-dependent manner and has a direct microbicidal effect on gram-positive bacteria (Brandl et al., 2007; Cash et al., 2006; Ismail et al., 2011; Mukherjee et al., 2009).”
• Impact of antibiotics on the human microbiome and consequences for host health (2022, background): “Germ‐free mice colonized with conventional or human mi- crobiota or specific probiotic species or LPS demonstrated increased production of antimicrobial peptides like REGIII‐γ, boosting the in- nate immune response (Brandl et al., 2008; Cash et al., 2006; Natividad et al., 2013).”
• Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota (2007, background): “How does intestinal inflammation subvert colonization resistance? The inflammation involves increased secretion of antibacterial peptides and lectins [21, 22 ] and mucins (B. Stecher and W. Hardt, unpublished data), phagocyte infiltration/transmigration, and release of oxygen and nitrogen radicals.”
• Innate IL-17-producing cells: the sentinels of the immune system (2010, background): “REG3γ is a soluble C-type lectin produced by Paneth cells and interacts directly with the bacterial cell wall to promote its anti-microbial activit”