Mitochondrial ROS signaling in organismal homeostasis.

By G. Shadel, T. Horvath. Cell, 2015

1,207 citations recorded by the source corpus.

Generation, transformation, and utilization of organic molecules in support of cellular differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes, mitochondrial oxygen consumption plays a central role in these processes. During the process of oxidative phosphorylation, mitochondria utilize oxygen to generate ATP from organic fuel molecules but in the process also produce reactive oxygen species (ROS). While ROS have long been appreciated for their damage-promoting, detrimental effects, there is now a greater understanding of their roles as signaling molecules. Here, we review mitochondrial ROS-mediated signaling pathways with an emphasis on how they are involved in various basal and adaptive physiological responses that control organismal homeostasis.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b7db3c3b47b0a7ec9ad9dc22c9083b9c7885ffc4

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In Molecular Biology

1. E. White
2. W. Zong
3. Joshua D. Rabinowitz
4. Guido Kroemer
5. Y. Fouad
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In Physiology

1. E. White

Citations in the corpus

• Mitochondria and Cancer (2016, background): “The reactive oxygen species (ROS) generated in mitochondria as a byproduct of the ETC can activate signal transduction pathways such as that of MAP kinase and the HIFs (in normoxia is referred to as pseudohypoxia) (Shadel and Horvath, 2015; Sullivan and Chandel, 2014).”
• Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement (2020, background): “phosphorylation signaling [26,27], and cell growth and differentiation [28,29].”
• Mitochondria ROS and mitophagy in acute kidney injury (2022, background): “Mitochondria utilize oxygen to generate adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) which is one of sources of mitochondrial ROS (mtROS) [10].”