The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

By Jianbin Huang, Shian Wu, Jose A. Barrera, K. Matthews, Duojia Pan. Cell, 2005

1,872 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7ceb1766dcaf5bc43df8997a6d9e4f8c5b6c88e

How researchers see this paper

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In Cell Biology

1. K. Guan
2. G. Halder
3. Bin Zhao
4. Fa-Xing Yu
5. Duojia Pan
6. S. Piccolo
7. M. Cordenonsi
8. Xaralabos Varelas

In Molecular Biology

1. K. Guan
2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Fa-Xing Yu
6. S. Piccolo
7. Xaralabos Varelas
8. M. Cordenonsi

Citations in the corpus

• Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. (2007, background): “The Wts/ Mats complex inhibits Yorkie (Yki), a transcription coactivator (Huang et al. 2005), possibly via direct phosphorylation, although the precise mechanism has yet to be determined.”
• Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. (2006, background): “Although the 11q22 amplicon has been observed in several tumor types, previous studies have not agreed on the likely driver gene(s), in part, because validation was lacking (Dai et al., 2003; Snijders et al., 2005; Bashyam et al., 2005; Imoto et al., 2001).”
• Hippo signaling in organ size control. (2007, background): “While the kinase cascade leading from Hpo to Wts and then to Yki is well established (Wu et al. 2003; Huang et al. 2005), we know very little about how this biochemical pathway is executed at the cellular level.”
• The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. (2008, background): “Furthermore, YAP can bind to and stimulate the transactivating activity of all four TEAD/TEF family members (Vassilev et al., 2001).”
• Mechanisms of Hippo pathway regulation (2016, positive): “In Drosophila, Yki binds to promoter regions to mediate transcriptional activation (Oh et al. 2013; Ikmi et al. 2014).”
• The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. (2008, methodology): “For coimmunoprecipitation assays, HA-Yki, HA-Yki, and V5-Wts constructs have been described previously (Huang et al., 2005).”
• The Hippo pathway: regulators and regulations. (2013, background): “3A), both resulting in inactivation of YKi/YAP/ TAZ.”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “In Drosophila, some common Yki target genes areBantam, diap1, and cyclin E, which maymediate the effect of Yki in inhibiting cell death and promoting cell proliferation (Huang et al., 2005; Nolo et al., 2006; Tapon et al., 2002; Thompson and Cohen, 2006).”
• CDK8/9 drive Smad transcriptional action, turnover and YAP interactions in BMP and TGFβ pathways (2009, positive): “We show that ALP activation of Smad1 involves YAP (Yes-associated protein, also known as YAP1 or YAP65), the end target of the Hippo pathway (Huang et al., 2005), which mediates cell-contact growth inhibition, organ size control, and tumor suppression (Dong et al.”
• YAP/TAZ at the roots of cancer (2016, background): “Yorkie was identified only in 2005 as Warts interacting protein (Huang et al., 2005).”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “Genetic analysis placed yki downstream of hpo, sav or wts, and biochemical studies demonstrated that Wts directly phosphorylates and inactivates Yki in a Hpo-regulated manner (Huang et al., 2005).”
• Mst1 and Mst2 maintain hepatocyte quiescence and suppress the development of hepatocellular carcinoma through inactivation of the Yap1 oncogene (2009, positive): “Yorkie’s actions are pro-proliferative and anti-apoptotic, and elimination of Yorkie is epistatic to loss of function of all of the upstream elements named above (Huang et al., 2005).”