The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

By Shian Wu, Yi Liu, Yonggang Zheng, Jixin Dong, Duojia Pan. Developmental Cell, 2008

679 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4ae8dd86a7c634fd98db4a3b35f6f1a13fecf1ad

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In Cell Biology

1. K. Guan
2. G. Halder
3. Bin Zhao
4. Fa-Xing Yu
5. S. Piccolo
6. Randy L. Johnson
7. Duojia Pan
8. M. Cordenonsi

In Molecular Biology

1. K. Guan
2. Bin Zhao
3. Duojia Pan
4. G. Halder
5. Randy L. Johnson
6. Fa-Xing Yu
7. E. Olson
8. S. Piccolo

Citations in the corpus

• Hippo pathway effector Yap promotes cardiac regeneration (2013, background): “The majority of the actions of Yap and Taz have been ascribed to their association with TEAD transcription factors (43, 44), and a dominant negative TEAD mutant was shown to be sufficient to block the proliferative activity of Yap in cardiomyocytes (34).”
• Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “In Drosophila, Scalloped (Sd) is a transcription factor and key partner of Yki that mediates the function of Yki in tissue growth (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008; Zhao et al., 2008).”
• Metabolic control of YAP and TAZ by the mevalonate pathway (2014, background): “factor (RUNX) 1 and 2 (Yagi et al., 1999) as well as p73 (Strano et al.”
• Hippo signaling: growth control and beyond (2011, background): “At the center of the Hippo pathway are two kinases, the Ste20-like kinase Hpo and the nuclear Dbf2-related (NDR) family kinase Wts, that form a kinase cascade (Harvey et al., 2003; Jia et al., 2003; Justice et al., 1995; Pantalacci et al., 2003; Udan et al., 2003; Wu et al., 2003; Xu et al., 1995).”
• The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain (2012, background): “Initial insight into the importance of this family of transcription factors came from work in Drosophila showing that regulation of proliferation by the YAP homolog, Yorkie, required interaction with the TEF/ TEAD protein, Scalloped (38).”
• The Hippo pathway: regulators and regulations. (2013, background): “YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death (Vassilev et al. 2001; Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008; Zhao et al. 2008).”
• Mechanisms of Hippo pathway regulation (2016, background): “Yki regulates gene transcription through interacting with the Scalloped (Sd) transcription factor (Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008).”
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. (2010, background): “2009), and their Drosophila homolog Sd in mediating the functions of Yki (Goulev et al. 2008; Wu et al. 2008; L Zhang et al. 2008).”
• The Hippo Signaling Pathway in Development and Disease (2019, background): “Not only were they identified as Yki/YAP-binding proteins in multiple unbiased protein-protein interaction screens in both Drosophila and mammals (Vassilev et al., 2001; Wu et al., 2008), they were also shown to bind to various Hippo target genes such as diap1 (Koontz et al.”
• The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals (2010, background): “…the on- D coprotein Yki (Huang et al., 2005) by excluding the latter from the nucleus (Dong et al., 2007; Oh and Irvine, 2008), where it normally functions as a coactivator for the TEAD/TEF family transcription factor Scalloped (Sd) (Wu et al., 2008; Zhang et al., 2008; Goulev et al., 2008).”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “Sd directly binds to a minimal 26 bp Hippo response element (HRE) that confers Hippo-dependent transcriptional regulation of diap1, a well characterized Hippo target gene (Wu et al., 2008).”
• TEAD mediates YAP-dependent gene induction and growth control. (2008, background): “During the preparation of this manuscript, it was reported that Sd mediates Hippo signaling downstream from Yki (Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008).”
• The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. (2010, background): “Consistent with the mammalian studies, Yki functions mainly through scalloped (Sd), which is the Drosophila TEAD ortholog, to promote tissue growth (Wu et al. 2008; L Zhang et al. 2008).”
• The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. (2009, background): “These activities are mediated by a Tead protein, Scalloped (Goulev et al., 2008; Wu et al., 2008; Zhang et al., 2008b).”