A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory

By C. Bourgeois, B. Rocha, Corinne Tanchot. Science, 2002

767 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c768c460ea0fbf1f475f12b676c3de0ddc2ecc50

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In Immunology

Citations in the corpus

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon (2003, background): “This was notable, given reports that some 'CD4-dependent' CD8 responses in fact are defective only in terms of their ability to make a secondary response to antige”
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection (2004, background): “Discussion Even though a primary CD8 + T cell response may seem to be independent of CD4 + T cells, there is a requirement for CD4 help for the subsequent generation of stable, protective CD8 memor”
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation (2003, background): “It has been proposed that CD4 + T cells, through CD40L, may imprint a unique 'molecular signature' on effector CD8 + T cells, endowing them with their capacity for improved memory cell functio”
Helping the CD8+ T-cell response (2004, background): “One set of results indicates that the primary CD8 + T-cell response to non-inflammatory, cellular antigen is in fact help independent, and help during the priming phase is required solely to programme the CTL so that it can be successfully restimulated after a secondary exposure to antige”
Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “Finally, evidence suggests that direct ligation of CD40 on naive CD8 + T cells by CD40L on CD4 + T cells can enhance the generation of memory CD8 + T cell”
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death (2005, background): “jpg" NDATA ITEM> ]> The ‘help’ provided by CD4 p T lymphocytes during the priming of CD8 p T lymphocytes confers a key feature of immune memory: the capacity for autonomous secondary expansion following re-encounter with antige”