CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

By E. Janssen, N. Droin, E. Lemmens, M. Pinkoski, S. Bensinger, B. Ehst, T. Griffith, Douglas R. Green, S. Schoenberger. Nature, 2005

649 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3852475cebab57fad749ea933fdb9cfcef6fecf7

How researchers see this paper

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In Immunology

1. Guido Kroemer
2. E. Wherry
3. K. Palucka
4. V. Badovinac
5. Jacques Banchereau
6. L. Zitvogel
7. S. Kaech
8. J. Harty

Citations in the corpus

• Immunogenic and tolerogenic cell death (2009, background): “or die as a result of activation-induced cell death following subsequent exposure to antige”
• Expanding roles for CD4+ T cells in immunity to viruses (2012, background): “It is thought that CD8 + T cells that are helped by CD4 + T cells downregulate TRAIL expression and become less susceptibl”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “The result of defective CD4+ T cell help is the generation of a population of antiviral CD8+ T cells that largely resembles TEM cells, responds poorly to rechallenge, and in some cases expresses the death receptor, Trail (Badovinac et al., 2006; Janssen et al., 2005).”
• Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “However, the clinical success was limited (Rosenberg et al., 2005), possibly because of the lack of CD4+ T cell help, which we now know is necessary for the generation of potent CTLs and long-lived memory CD8+ T cells (Janssen et al., 2005; Filipazzi et al., 2012).”
• Therapeutic cancer vaccines. (2010, background): “CD4+ T cells are needed for optimal and sustained effector CD8+ T cell responses (120–124) as well as induction and maintenance of CD8+ memory (125, 126).”
• Shaping and reshaping CD8+ T-cell memory (2008, result): “These results were extended by the observation that, in the absence of CD4 + T cells during priming, CD8 + T cells exhibited heightened expression of the death receptor TRAIL (tumour-necrosis factor (TNF)-related apoptosis-inducing ligand), and underwent apoptosis when restimulate”