Tetraspanins: push and pull in suppressing and promoting metastasis

By M. Zöller. Nature Reviews. Cancer, 2009

674 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c736ae2c8149d535f883eb2752c240aa751a369d

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In Cell Biology

1. Michael Zhuo Wang
2. Richard J. Simpson
3. Jeffrey L. Wrana
4. G. Raposo
5. M. Simons
6. W. Stoorvogel
7. Laura M Doyle

In Immunology and Allergy

1. Michael Zhuo Wang
2. Richard J. Simpson
3. G. Raposo
4. M. Simons
5. W. Stoorvogel
6. Laura M Doyle

In Molecular Biology

1. G. Raposo
2. Richard J. Simpson
3. David W. Greening
4. W. Stoorvogel
5. Rong Xu
6. Michael Zhuo Wang
7. Laura M Doyle
8. M. Simons

Citations in the corpus

• Exosomes--vesicular carriers for intercellular communication. (2009, background): “It is also possible that tetraspanins are part of the sorting system as they are known to form oligomers (tetraspanin webs) by interacting with other tetraspanins and also with a variety of transmembrane and cytosolic proteins [28].”
• Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis (2019, background): “the cell’s plasma membrane, it is easily understood that MVs contain mainly cytosolic and plasma membrane associated proteins, especially proteins known to cluster at the plasma membrane surface, such as tetraspanins [89,90].”
• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “, 2007), but these mechanisms have been summarized excellently elsewhere (Zöller, 2009; Rak, 2010; Peinado et al., 2011).”
• Exosomes Derived from Mesenchymal Stem Cells (2014, background): “Exosomes from various cell types have been implicated in important physiological and pathological processes such as disposal of unwanted proteins, antigen presentation, genetic exchange, immune responses, angiogenesis, inflammation, tumor metastasis, and spreading of pathogens or oncogenes [33,34], ”
• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Exosomes originating from a variety of different cells share common structural and functional proteins, such as Rab GTPase, SNAREs, annexins, Alix, Tsg101, and tetraspanins [13,14] and the glycosylphosphatidylinositol-anchored molecules, flotillin, cholesterol, sphingomyelin, and hexosylceramides [1”
• Exosomes and their roles in immune regulation and cancer. (2015, background): “13 g/mL) and protein content, includng endosome-derived (endosomal sorting complex required for ransport proteins; ESCRTs, such as Alix and Tsg101), sorting- and rafficking-related (endosomal Rab GTPases) and cell membraneerived (tetraspanins, CD63, CD81 and CD82) [17,18].”
• Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. (2012, methodology): “Therefore, we knocked down Cd63, Cd81, Cd82, Igsf8, and Ptgfrn using siRNA in L cells and found that downregulation of Cd81 expression inhibited ACM-induced MDA-MB-231 cell C motility (Figure S6B) close to that of unstimulated cells.”
• Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “Other studies confirmed that tetraspanins are abundant in EVs from other sources (Zöller, 2009).”