Exosomes Derived from Mesenchymal Stem Cells

By Bo Yu, Xiaomin Zhang, Xiaorong Li. International Journal of Molecular Sciences, 2014

770 citations recorded by the source corpus.

The functional mechanisms of mesenchymal stem cells (MSCs) have become a research focus in recent years. Accumulating evidence supports the notion that MSCs act in a paracrine manner. Therefore, the biological factors in conditioned medium, including exosomes and soluble factors, derived from MSC cultures are being explored extensively. The results from most investigations show that MSC-conditioned medium or its components mediate some biological functions of MSCs. Several studies have reported that MSC-derived exosomes have functions similar to those of MSCs, such as repairing tissue damage, suppressing inflammatory responses, and modulating the immune system. However, the mechanisms are still not fully understood and the results remain controversial. Compared with cells, exosomes are more stable and reservable, have no risk of aneuploidy, a lower possibility of immune rejection following in vivo allogeneic administration, and may provide an alternative therapy for various diseases. In this review, we summarize the properties and biological functions of MSC-derived exosomes and discuss the related mechanisms.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/71b71459960d6644c8f3bddde83934fb50d56074

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Citations in the corpus

• Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine (2018, background): “In fact, MSC-derived EVs (MSC-EVs), or cell-free therapies, in contrast to treatments based on whole cells, are easier to manage and safer due to lower amounts of membrane-bound proteins such as MHC molecules and their inability to directly form tumors [19].”
• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “The nanoscale exosomes can easily shuttle through tissues and biological barriers to transfer microRNAs, lipids, and proteins, thus they have been adapted as therapeutic agents.(84) For example, exosomal miR-125b-5p was shown to mediate the therapeutic effects of MSCs in myocardial infarction and is”