Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.

By V. Luga, Liang Zhang, A. Viloria‐Petit, A. Ogunjimi, M. Inanlou, E. Chiu, M. Buchanan, A. Hosein, M. Basik, Jeffrey L. Wrana. Cell, 2012

1,273 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b8dbe66ae0f2470ab14b261e301d1c0fbf2b4d93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Raghu Kalluri
2. C. Théry
3. Marina Colombo
4. G. Raposo
5. X. Breakefield
6. W. Stoorvogel
7. P. Vader
8. Jan Lötvall

In Molecular Biology

1. Raghu Kalluri
2. C. Théry
3. G. Raposo
4. Marina Colombo
5. X. Breakefield
6. W. Stoorvogel
7. P. Vader
8. Jan Lötvall

Citations in the corpus

• Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “[8,82] but not enriched comparedwith the parental cells (ratio=1), whereas it is absent in the p”
• Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “2 mm filters and ultracentrifugation for 2 hr, as previously described (Li et al., 2012; Luga et al., 2012).”
• Exosomes in cancer: small particle, big player (2015, background): “demonstrate that fibroblast-secreted exosomes mobilize autocrine Wnt-planar cell polarity (PCP) signaling to drive breast cancer cell invasion and metastasis [42].”
• Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper (2015, methodology): “Indeed, EVs purified using a combination of SEC and IEC show a potent functional activity (308).”
• Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “Recent studies reported the association of membranebound morphogens to EVs, including Wnt (Gross et al., 2012; Luga et al., 2012; Beckett et al., 2013), and the Notch ligand DII4 (Sheldon et al., 2010).”
• In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior (2015, background): “Vice versa, EVs from stromal cells—for example, fibroblasts and activated T cells—have been shown to alter the protrusive and migratory behavior of tumor cells (Cai et al., 2012; Luga et al., 2012).”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “…to the future sites of metastasis (Peinado et al. 2012), by directly seeding tumor-draining lymph nodes before further migration of tumor cells themselves (Hood et al. 2011), or by increasing local motility of tumor cells via a complex interplay with surrounding fibroblasts (Luga et al. 2012).”
• Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “[42] show that fibroblast-derived exosomes, which are positive for the tetraspanin Cd81, activate an autocrine Wntsignaling pathway in breast cancer cells to facilitate migration.”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “For example, Luga and colleagues recently demonstrated that fibroblast-secreted exosomes promote breast cancer cell aggressiveness by protrusive activity and motility via Wntplanar cell polarity signaling that was translated into enhanced metastasis [192].”