The complex life of simple sphingolipids

By A. Futerman, Yusuf A. Hannun. EMBO Reports, 2004

668 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c6b74948665938d98dff2cac4d178c27df64b601

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Citations in the corpus

Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript fludarabine, etoposide, and gemcitabine increase ceramide generation through the de novo pathway, or via activation of SMases (Futerman and Hannun, 2004; Ogretmen and Hannun, 2004).”
(Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1 (2007, background): “An increasing amount of evidence suggests that different ceramide species mediate different responses within cells (24).”
Lip1p: a novel subunit of acyl‐CoA ceramide synthase (2005, background): “Sphingolipids also function in membrane trafficking, influencing the intracellular targeting of glycosylphosphatidylinositol-anchored proteins and regulating the internalization step of endocytosis (Dickson, 1998; Dickson and Lester, 2002; Merrill, 2002; Futerman and Hannun, 2004).”
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. (2011, positive): “In addition to being important membrane lipids, sphingolipids play a role in signaling, as these lipids are implicated in cell growth, differentiation, senescence, apoptosis, and cancer (Futerman & Hannun 2004, Ogretmen & Hannun 2004).”
Lipid signalling in disease (2008, background): “; when phosphorylated by lipid kinases, however, sphingosine is converted into sphingosine-1-phosphate (S1P), which promotes cell growth and proliferation by a still poorly understood intracellular action as well as by extracellular signalling through a set of different G protein-coupled receptors ”
Kinetic characterization of mammalian ceramide synthases: Determination of K m values towards sphinganine (2007, background): “Ceramide is both an intermediate in the biosynthetic pathway of sphingolipids and an important bioactive lipid involved in a number of molecular signalling pathways [1–4].”
Membrane organization and lipid rafts. (2011, background): “However, biological membranes are mostly lamellar, implying that lipids are arranged both with each other and with proteins (e.g., through selective macromolecular assemblies, specific bilayer asymmetries) to make the lamellar state more favorable.”