Lip1p: a novel subunit of acyl‐CoA ceramide synthase

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Mammalian Ceramide Synthases (2010, background): “Interestingly, when human CerS5 was expressed in a yeast Dlag1Dlac1DLip1 mutant (71), it was able to synthesize C16-ceramides and the mutant survived in the absence of the C26-ceramides that are normally found in yeast.”
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas (2007, background): “Importantly, although the yeast LAG1 requires LAC1 and Lip1 for the generation of ceramide (34), mouse LASS5 was shown to be a bona fide (dihydro)ceramide synthase without any detectable requirement for any associated proteins for its enzyme activity (31), suggesting distinct regulatory mechanisms f”
Transmembrane topology of ceramide synthase in yeast. (2006, unknown): “Cell 12, 3417–3427; Vallee and Riezman (2005) EMBO J.”