(Dihydro)ceramide Synthase 1–Regulated Sensitivity to Cisplatin Is Associated with the Activation of p38 Mitogen-Activated Protein Kinase and Is Abrogated by Sphingosine Kinase 1

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CERAMIDE SYNTHASE 1 IS REGULATED BY PROTEASOMAL MEDIATED TURNOVER (2009, methodology): “CerS1 is phylogenetically distinct, lacks a HOX-like domain [5], preferentially uses C18 acyl CoA as a substrate [13], is expressed (mRNA) most abundantly in the brain and heart [10], increases sensitivity to specific chemotherapeutic agents [17,20], and is associated with the alteration of C18 cera”
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing (2009, unknown): “We previously demonstrated that two chemotherapeutic drugs, cisplatin (which forms bulky adducts on DNA by crosslinking adjacent purines) and doxorubicin (which intercalates DNA), induce a robust and specific translocation of C-terminal HA-tagged CerS1 (CerS1-HA), but not CerS4 or CerS5, from its no”
Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “Recently, a role for LASS1 in the regulation of sensitivity to various chemotherapeutic agents has been further confirmed in an independent study using human cancer cell lines in situ (Min et al., 2007).”