Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.

By Sandrine Étienne-Manneville, A. Hall. Cell, 2001

934 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c6b29f5a53cec1c4cc7eabbc28dea31df8b2e795

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In Cell Biology

Citations in the corpus

Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Blocking integrins by using Arg–Gly–Asp (RGD) peptides or blocking downstream signaling by inhibiting Src activity leads to loss of Cdc42 activation and inhibition of cell polarity (Etienne-Manneville and Hall 2001).”
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro (2007, methodology): “Although it is developed and more suitable for measuring migration of population of cells, the in vitro scratch assay has also been combined with other techniques, such as microinjection or gene transfection, to assess the effects of expression of exogenous genes on migration of individual cell”
Cdc42 - the centre of polarity (2004, background): “Mammalian Par6 and the atypical PKC PKCζ are involved in microtubule-mediated-centrosome reorientation during wound-induced astrocyte migration and during shear-stressinduced endothelial cell polarization (Etienne-Manneville and Hall, 2001; Tzima et al., 2003).”
Non-muscle myosin II takes centre stage in cell adhesion and migration (2009, neutral): “The MTOC and Golgi apparatus reposition in front of the nucleus towards the direction of protrusio”
Cell adhesion: integrating cytoskeletal dynamics and cellular tension (2010, background): “The partitioning defective 3 (PAR3)– or PAR6–protein kinase Cα (PKCα) complex is also implicated in cell polarit”
Random versus directionally persistent cell migration (2009, background): “Integrin engagement by components of the ECM can locally activate CDC42 at subregions of the plasma membran”
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. (2002, background): “…to their well-established roles in controlling the actin cytoskeleton, Rho GTPases regulate the microtubule cytoskeleton, cell polarity, gene expression, cell cycle progression, and membrane transport pathways (Van Aelst and D’Souza-Schorey 1997; Daub et al. 2001; Etienne-Manneville and Hall 2001).”
Nanopattern-induced changes in morphology and motility of smooth muscle cells. (2005, background): “Previous studies show that microtubules (MT) are essential for the polarization of many cell types [31,33], and cell migration involves the MT and actin cytoskeletons.”