Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

By P. Kucharzewska, H. Christianson, J. Welch, Katrin J. Svensson, E. Fredlund, Markus Ringnér, M. Mörgelin, E. Bourseau-Guilmain, J. Bengzon, Mattias Belting. Proceedings of the National Academy of Sciences of the United States of America, 2013

883 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c5ae5625f221e092f2eb1abdc50aab1a9143a52b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Raghu Kalluri
2. C. Théry
3. Marina Colombo
4. A. Llorente
5. G. Raposo
6. X. Breakefield
7. W. Stoorvogel
8. M. Wood

In Cell Biology

1. C. Théry
2. Marina Colombo
3. F. Sánchez‐Madrid
4. María Yáñez-Mó
5. M. Wood
6. H. Peinado
7. Zoraida Andreu
8. M. Mittelbrunn

In Molecular Biology

1. Raghu Kalluri
2. C. Théry
3. G. Raposo
4. Marina Colombo
5. X. Breakefield
6. A. Llorente
7. W. Stoorvogel
8. P. Vader

Citations in the corpus

• Extracellular Vesicles: Unique Intercellular Delivery Vehicles. (2017, background): “Compared to EVs produced under normoxic conditions, the EVs released from hypoxic tumors act to increase the activation of the ERK1/2 MAPK, PI3K/AKT, and FAK pathways in recipient endothelial cells, resulting in more endothelial cell sprouting - an early step in neo-vascularization [117].”
• Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “The uptake of cancer cell-derived exosomes by endothelial cells stimulates angiogenesis under hypoxic conditions by stimulating the proangiogenic secretome of endothelial cells [68].”
• SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “Exosomes derived from cells grown under hypoxic conditions accelerate tumor growth and angiogenesis more potently than normoxia-derived exosomes in malignant brain tumor gliobastoma [116].”
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “Hypoxia, a pathological situation observed in the core of large tumors or upon vascular injury, modifies the protein and RNA composition of EVs released by endothelial (de Jong et al. 2012) and tumor (Kucharzewska et al. 2013) cells.”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “flect the hypoxic status of glioma cells [165].”
• The biology, function, and biomedical applications of exosomes (2020, neutral): “Exosomes fromhypoxic glioblastoma (GBM) cells induce proangiogenic programming of endothelial cells and GBM cell proliferation (166).”
• Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity (2013, methodology): “To exclude that the HSPG dependence is restricted to exosomes from U-87 MG cells, we performed experiments with two additional, patient-derived tumor cell lines (U118 MG and LN18) that previously have been shown to produce exosomes (30).”
• Exosomes in cancer: small particle, big player (2015, background): “Exosomes derived from hypoxic glioblastoma cells are more potent to induce angiogenesis [32].”
• The biology and function of exosomes in cancer. (2016, background): “Exosome biogenesis is observed in immune cells, mesenchymal stem cells, fibroblasts, neurons, endothelial cells (ECs), and epithelial cells.”
• Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “Exosomes derived from highly malignant glioblastoma multiforme (GBM) cells growing in hypoxic conditions induce angiogenesis by stimulating cytokine and growth factor secretion by endothelial cells, thereby promoting pericyte migration (Kucharzewska et al., 2013).”