Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

By Song Hong, K. Gronert, P. Devchand, Rose-Laure Moussignac, C. Serhan. Journal of Biological Chemistry, 2003

1,015 citations recorded by the source corpus.

Docosahexaenoic acid (DHA, C22:6) is highly enriched in brain, synapses, and retina and is a major ω-3 fatty acid. Deficiencies in this essential fatty acid are reportedly associated with neuronal function, cancer, and inflammation. Here, using new lipidomic analyses employing high performance liquid chromatography coupled with a photodiode-array detector and a tandem mass spectrometer, a novel series of endogenous mediators was identified in blood, leukocytes, brain, and glial cells as 17S-hydroxy-containing docosanoids denoted as docosatrienes (the main bioactive member of the series was 10,17S-docosatriene) and 17S series resolvins. These novel mediators were biosynthesized via epoxide-containing intermediates and proved potent (pico- to nanomolar range) regulators of both leukocytes reducing infiltration in vivo and glial cells blocking their cytokine production. These results indicate that DHA is the precursor to potent protective mediators generated via enzymatic oxygenations to novel docosatrienes and 17Sseries resolvins that each regulate events of interest in inflammation and resolution.

Subfields: Aquatic Science, Biochemistry, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/c53204f7bd0c034cf3789a82ec586a076074c015

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aquatic Science

1. Alexander Wacker
2. M. Kainz
3. C. Parrish
4. M. T. Arts
5. S. Colombo
6. C. Serhan
7. D. Müller-Navarra

In Biochemistry

1. C. Serhan
2. B. Levy
3. Undurti N. Das
4. D. Gilroy
5. Chia Nan
6. C. Buckley
7. S. Leng
8. H. Aukema

In Nutrition and Dietetics

1. C. Serhan
2. B. Levy
3. D. Gilroy
4. Undurti N. Das
5. Chia Nan
6. C. Buckley
7. S. Leng
8. H. Aukema

Citations in the corpus

• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “bioactive products identified within the resolution phase of acute sterile inflammation (illustrated in top panel of Figure 1) that activate pro-resolving mechanisms (Hong et al., 2003; Serhan et al., 2000; Serhan et al., 2002).”
• Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators (2008, background): “Unexpectedly, two of these recently described lipid mediator families, the resolvins and protectins, are biosynthesized from precursor essential omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA”
• The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. (2005, background): “, 2000) inhibitors and LOX metabolites (Hong et al., 2003; Serhan et al., 2000a, b; Serhan and Oliw, 2001).”
• A fundamental dichotomy in long-chain polyunsaturated fatty acid abundance between and within marine and terrestrial ecosystems (2017, background): “DHA is directly involved in several processes in the brain including neurotransmission, cell survival, and prevents neuro-inflammation (and thereby mood and cognition, Bazinet and Layé 2014), and also acts as a precursor for docosatrienes, involved in anti-inflammation (Hong et al. 2003).”