Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

By Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang, F. Shao. Nature, 2017

2,745 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c487e22947e2c7262e4b31c525a8993743e8c32a

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Citations in the corpus

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “and CASP5, depending on the initiating stimulus [612, 613].”
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps (2018, result): “This is in line with other reports showing that apoptotic caspases can process the gasdermin family member DFNA5 into a lytic form to drive secondary necrosis (26, 27).”
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity (2020, background): “Interventions with certain chemotherapeutic drugs evoke a switch from caspase 3-dependent apoptosis to pyroptosis [111, 112].”
Role of pyroptosis in inflammation and cancer (2022, background): “Doxorubicin, a common chemotherapy drug, triggers caspase-3-dependent pyroptosis, producing antitumor effects in melanoma cell lines [178, 272].”
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells (2020, background): “Rather, these enzymes cleave various downstream substrates, including gasdermins, which in turn can both initiate and implement particular cell death programs (24, 25, 33).”
Gasdermins: Effectors of pyroptosis (2017, methodology): “Previously, gasdermin E and DFNB59 were proposed to be excluded from the gasdermin family, and instead called gasdermin-related proteins[11], however we prefer to simplify the nomenclature by including all six genes in a single gasdermin family, given recent advances[12,13].”
Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, background): “This necrotic cell death might contribute to hearing loss in GSDMA3 spontaneous mutations that are associated with deafness (155).”
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “However, in some tumor cell lines, the expression level of GSDME was lower than that in normal cell lines, leading to the accidental injury of normal tissues during chemotherapy [38, 124].”