Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
By G. Amarante-Mendes, Sandy Adjemian, L. M. Branco, Larissa C. Zanetti, R. Weinlich, K. Bortoluci. Frontiers in Immunology, 2018
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Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns—PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns—DAMPs). They emerged phylogenetically prior to the appearance of the adaptive immunity and, therefore, are considered part of the innate immune system. Signals derived from the engagement of PRRs on the immune cells activate microbicidal and pro-inflammatory responses required to eliminate or, at least, to contain infectious agents. Molecularly controlled forms of cell death are also part of a very ancestral mechanism involved in key aspects of the physiology of multicellular organism, including the elimination of unwanted, damaged or infected cells. Interestingly, each form of cell death has its particular effect on inflammation and on the development of innate and adaptive immune responses. In this review article, we discuss some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d9c7a1357b068e5327eba21851c3ee6d2ec359a4
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Citations in the corpus
- Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “Pathogen-associated molecular patterns (PAMPs), as small molecular motifs conserved in a class of microorganisms, can be sensed by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) to activate innate immune responses, which effectively protect the host from infection.(31) LPS”