Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
By Ronghua Tang, Jin Xu, Bo Zhang, Jiang Liu, C. Liang, J. Hua, Qingcai Meng, Xianjun Yu, S. Shi. Journal of Hematology & Oncology, 2020
1,070 citations recorded by the source corpus.
In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to these agents. The induction of cell death mechanisms other than apoptosis has gradually emerged as a new cancer treatment strategy because most tumors harbor innate resistance to apoptosis. However, to date, the possibility of combining these two modalities has not been discussed systematically. Recently, a few studies revealed crosstalk between distinct cell death mechanisms and antitumor immunity. The induction of pyroptosis, ferroptosis, and necroptosis combined with ICIs showed synergistically enhanced antitumor activity, even in ICI-resistant tumors. Immunotherapy-activated CD8+ T cells are traditionally believed to induce tumor cell death via the following two main pathways: (i) perforin-granzyme and (ii) Fas-FasL. However, recent studies identified a new mechanism by which CD8+ T cells suppress tumor growth by inducing ferroptosis and pyroptosis, which provoked a review of the relationship between tumor cell death mechanisms and immune system activation. Hence, in this review, we summarize knowledge of the reciprocal interaction between antitumor immunity and distinct cell death mechanisms, particularly necroptosis, ferroptosis, and pyroptosis, which are the three potentially novel mechanisms of immunogenic cell death. Because most evidence is derived from studies using animal and cell models, we also reviewed related bioinformatics data available for human tissues in public databases, which partially confirmed the presence of interactions between tumor cell death and the activation of antitumor immunity.
Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/a2a7adb6bedb72698d5d4ad0d07b9ac55aa460cc
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Citations in the corpus
- Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “In the past, perforin has been thought to be the only protein responsible for pore formation on CD8+ T cells,(208) but it was suggested by the authors that GSDMD could be a new pore-forming protein utilized by effector T cells to form pores in tumor cells.(40) Nevertheless, the mechanism of GSDMD tr”
- Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Emerging evidence has demonstrated that CD8 + T cells inhibit tumor cells via induction of necroptosis, pyroptosis, ferroptosis [169, 336, 337], and possibly cuproptosis [338].”