Entrainment of the circadian clock in the liver by feeding.

By K. Stokkan, S. Yamazaki, H. Tei, Y. Sakaki, M. Menaker. Science, 2001

1,773 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/c42d2811b224d24c16aaa7b616f08805821c6ab0

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In Endocrine and Autonomic Systems

In Physiology

Citations in the corpus

Coordination of circadian timing in mammals (2002, background): “The SCN entrain some slave oscillators (for example, liver) by regulating the rest/activity cycle and thereby the timing of feeding behaviou”
The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Strikingly, daytime-restricted feeding of nocturnal rodents inverts the phase of gene expression in peripheral organs, thereby uncoupling peripheral clocks from the SCN (230, 233).”
Harmonics of Circadian Gene Transcription in Mammals (2009, background): “Previous experiments have shown that core clock components in the liver invert their phase by 12 h during restricted feeding [32].”
Adverse metabolic and cardiovascular consequences of circadian misalignment (2009, background): “In rodents, peripheral oscillators such as in the liver can be dissociated from the master oscillator in the hypothalamus by restricted daytime food access (22).”
A model of periodic oscillation for genetic regulatory systems (2002, methodology): “In this section, we use a simplified abstract two-gene model to qualitatively analyze periodic oscillations, such as circadian rhythms appearing in most organisms with day–night cycles [3], [7], [24], [25].”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, neutral): “While light-dark cycles are the predominant Zeitgebers (timing cues) for the SCN pacemaker, cyclic feeding behavior is a strong Zeitgeber for clocks operating in many peripheral tissues (Albrecht and Eichele, 2003; Damiola et al., 2000; Reppert and Weaver, 2002; Stokkan et al., 2001).”
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression (2009, methodology): “We hypothesized that these transcripts might be driven by systemic cues originating in the SCN, which is unperturbed by feeding pattern (3, 4).”
A web of circadian pacemakers. (2002, background): “Implants of mouse embryo fibroblaststhe phase of the SCN master clock (Damiola et al., 2000; Stokkan et al., 2001), irrespective of whether the animals (MEFs) from mice with different genotypes (Pando et al., 2002) may prove a powerful tool in the identificationsubjected to restricted feeding are…”
The Circadian Clock and Human Health. (2016, background): “feeding [8,10,18,19] is well established, setting up potential conflicts between SCN as an endogenous zeitgeber and social factors (mealtime).”
Molecular components of the Mammalian circadian clock. (2013, background): “The phase of the circadian rhythms of gene expression in the liver can be uncoupled from the rest of the body by providing food only when the animal would typically be asleep (Stokkan et al. 2001; Damiola et al. 2000).”
Time zones: a comparative genetics of circadian clocks (2001, background): “However, oscillating liver cells will take their phasing cues from feeding time rather than from the SCN if conflicte”
BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis (2004, background): “Asynchronous environmental cues, such as eating, also influence the autonomous behavior of peripheral clocks (Damiola et al. 2000; Stokkan et al. 2001).”
The “Other” Circadian System: Food as a Zeitgeber (2002, background): “Stokkan et al. (2001) entrained transgenic rats (Per 1-luc) to food access for 4 h per day during the light phase of the LD cycle.”
Circadian genes, rhythms and the biology of mood disorders. (2007, background): “This entrainment to food, or other non-photic stimuli, is controlled by SCN-independent pacemakers located in various regions of the brain and other organs (Stokkan et al., 2001;Stephan, 2002;Mieda et al., 2006).”
Physiological significance of a peripheral tissue circadian clock (2008, background): “However, when animals are placed on a daily feeding schedule that differs from the daily cycle of spontaneous feeding, peripheral tissue clocks, but not the SCN clock, are set to a new phase determined by the imposed feeding schedule (7, 12).”