Adverse metabolic and cardiovascular consequences of circadian misalignment

By F. Scheer, M. Hilton, C. Mantzoros, S. Shea. Proceedings of the National Academy of Sciences of the United States of America, 2009

2,198 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/26bedeef04632c84161970f531423a14018988ff

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In Endocrine and Autonomic Systems

In Physiology

Citations in the corpus

Circadian Timing of Food Intake Contributes to Weight Gain (2009, positive): “Circulating satiety hormones, such as leptin, may have a circadian variation independent of meal timing and be contributing to food intake levels as seen with humans on a circadian misaligned schedule (10).”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “Humans who eat and sleep 12 hr out of phase from their habitual patterns experience increased blood pressure, worsening of glucose tolerance, a reduction of the satiety hormone leptin, and a complete inverse pattern of the cortisol rhythm (Scheer et al., 2009).”
Light at night increases body mass by shifting the time of food intake (2010, background): “In humans even brief circadian misalignment results in adverse metabolic and cardiovascular consequences (34).”
Metabolic regulation of epigenetics (2012, background): “In humans, it has been shown that circadian misalignment could cause aberrant glucose response indicative of a prediabetic state (Scheer et al., 2009).”
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. (2014, background): “…into GF (legend on next page) 522 Cell 159, 514–529, October 23, 2014 ª2014 Elsevier Inc. cardiovascular disease, all disease states that have emerged in parallel in modern human populations (Archer et al., 2014; Buxton et al., 2012; Fonken et al., 2010; Scheer et al., 2009; Suwazono et al., 2008).”
The Circadian Clock and Human Health. (2016, background): “, to metabolism; arrows 7 and 9), predict metabolic syndromes [32,53,70,84,85].”
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences and Countermeasures (2016, neutral): “creases insulin secretion (128), 3 weeks of combined sleep”
Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Recently, forced circadian desynchronization (a simulation of shift work) in humans was shown to impact on neuroendocrine control of glucose metabolism and energetics (Scheer et al., 2009).”
Timing of food intake predicts weight loss effectiveness (2013, background): “This differential synchronization induced by abnormal feeding habits might produce unhealthy consequences also in humans (13).”
Sleep: a health imperative. (2012, neutral): “Over time, whole-body desynchronization may accelerate and lead to metabolic and cardiovascular disease, 15,16 cancer progression, 17 and death.”
Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption (2012, background): “In contrast, acute circadian misalignment results in a higher postprandial insulin response that is nonetheless inadequate (21).”