Time zones: a comparative genetics of circadian clocks

By M. W. Young, Steve A. Kay. Nature reviews genetics, 2001

1,159 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/2dce729e1494ef8ca89d9d3e71ff2437727a21fb

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In Endocrine and Autonomic Systems

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Citations in the corpus

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis (2004, background): “1994), transcription factors that compose the positive limb of an autoregulatory feedback loop in the core molecular clock (Young and Kay 2001; Reppert and Weaver 2002), also impairs circadian behavior.”
Network resilience (2020, background): “Another example is the circadian oscillation, which is generated by the negative regulation exerted by a protein on the expression of its own gene [366].”
Computational approaches to cellular rhythms (2002, background): “Experimental advances during the past decade have clarified the molecular bases of these circadian rhythms, first in Drosophila and Neurospora , and more recently in cyanobacteria, plants and mammal”
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004, background): “…with the Clock/Bmal1 complex to repress their own3 Department of Cell Biology transcription, forming a 24 hr long feedback loop, aThe Scripps Research Institute general mechanism conserved in many organisms (Dun-10550 North Torrey Pines Road lap, 1999; Panda et al., 2002b; Young and Kay, 2001).”
Physiological significance of a peripheral tissue circadian clock (2008, background): “I daily rhythms of physiology and behavior are driven by circadian clocks, cell-autonomous oscillators built on a molecular feedback loop (1).”
Variable tandem repeats accelerate evolution of coding and regulatory sequences. (2010, background): “This period is highly affected by external conditions (light/dark cycles, temperature), and different molecular mechanisms responsible for maintaining the period length constant have been identified (148).”
Social Jetlag: Misalignment of Biological and Social Time (2006, neutral): “…1 day) and have been shown for many biological functions, ranging from the sleep/wake cycle and physiology, e.g., temperature, melatonin, and cortisol (Bailey and Heitkemper, 1991, 2001; Duffy et al., 2001; Waterhouse et al., 2001) to gene expression (Clayton et al., 2001; Young and Kay, 2001).”
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. (2002, methodology): “…Genetics Baylor College of Medicine One Baylor Plaza activity of BMAL1/CLOCK heterodimers directly (Rep-Houston, Texas 77030 pert and Weaver, 2001; Young and Kay, 2001).2 Department of Molecular Pathology Molecular clockwork similar to that in SCN neurons3 Department of Pathology has been found…”