Physiological significance of a peripheral tissue circadian clock

By Katja A. Lamia, Kai-Florian Storch, C. Weitz. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,041 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/e9084f2cad530ad68210017259a34e65d8116eee

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Satchidananda Panda
2. J. Takahashi
3. U. Albrecht
4. C. Dibner
5. U. Schibler

In Endocrine and Autonomic Systems

1. J. Takahashi
2. Satchidananda Panda
3. U. Albrecht
4. C. Green
5. J. Mohawk
6. Steve A. Kay
7. David K. Welsh
8. C. Dibner

In Physiology

1. Satchidananda Panda
2. J. Takahashi
3. U. Albrecht
4. C. Green
5. S. Gill
6. C. Dibner
7. U. Schibler
8. J. Mohawk

Citations in the corpus

• Reprogramming of the Circadian Clock by Nutritional Challenge (2013, neutral): “, 2010) and circadian disruption can result in disorders such as diabetes, obesity, and cardiac disease (Antunes Lda et al., 2010; Doi et al., 2010; Drake et al., 2004; Fonken et al., 2010; Froy, 2010; Knutsson, 2003; Lamia et al., 2008; Sharifian et al., 2005; Suwazono et al., 2008).”
• A circadian clock in macrophages controls inflammatory immune responses (2009, background): “We know now that many peripheral tissues have autonomous circadian clocks, and we also know that these peripheral clocks are essential regulators of normal peripheral physiology (3, 27).”
• Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression (2009, methodology): “Additionally, in liver-specific clock-deficient mice, a subset of hepatic circadian transcripts was shown to oscillate in the presence of an intact SCN clock (12), which drives rhythmic feeding behavior (7).”
• Molecular Architecture of the Mammalian Circadian Clock (2013, background): “Disruption of the peripheral clock in the liver by targeted deletion of Bmal1 eliminates circadian regulation of glucose regulatory genes, which interferes with the export of hepatic blood glucose in a time-of-day-dependent manner and leads to a systemic disruption of blood glucose buffering over th”
• The mammalian circadian timing system: organization and coordination of central and peripheral clocks. (2010, background): “Elegant work by Weitz and colleagues (186) suggests that functional liver clocks contribute to glucose homeostasis by driving a daily rhythm of hepatic glucose export.”
• Suprachiasmatic Nucleus: Cell Autonomy and Network Properties (2010, background): “Genetic manipulations selectively disabling local oscillators have revealed that local clocks drive physiological rhythms in the retina (94) and liver (95), and that circadian regulation of gene expression in liver is driven partly by the liver clock and partly by signals emanating from the SCN (96)”
• CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “…control over many biological processes, including many aspects of metabolism such as xenobiotic detoxification (Gachon et al. 2006), glucose homeostasis (Lamia et al. 2008, Marcheva et al. 2010, So et al. 2009, Turek et al. 2005), and lipogenesis (Gachon et al. 2011, Le Martelot et al. 2009).”
• Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet (2012, neutral): “A number of mouse genetic models carrying wholebody- or tissue-specific perturbation of circadian oscillators (Cho et al., 2012; Kornmann et al., 2007; Lamia et al., 2008; Marcheva et al., 2010; Preitner et al., 2002; Turek et al., 2005) or key metabolic regulators (Andreelli et al.”